Sốt chưa rõ nguyên nhân (Fever of unknown origin_FUO) có nguồn gốc thuật ngữ từ năm 1961 do tác giả Petersdorf và Beeson đặt ra như một tình trạng bệnh có thân nhiệt của bệnh nhân trên 38,3°C ít nhất 3 đợt trong thời gian ít nhất ba tuần, mà không có một chẩn đoán nào xác định mặc dù một tuần đã điều tra ca bệnh trên các bệnh nhân nội trú. Tuy nhiên, vì các bệnh lý nền thường báo cáo như các tình trạng FUO kinh điển, các tình trạng như thế này không thể coi như một tình trạng không rõ nguồn gốc (“unknown origin”). Hơn nữa, bệnh sinh của sốt kéo dài có thể được giải quyết hoặc không giải quyết.Định nghĩa của sốt mà nguyên nhân không được giải quyết gọi là FUO thật (true FUO) thật là khó vì nó như một đích đang chuyển động, với sự tiến triển hàng định về hình ảnh và phân tích chỉ điểm sinh học. Do đó, tỷ lệ sốt có nguyên nhân không được giải quyết vẫn không thể biết được.
Về mặt tiên lượng, vì có nhiều tình trạng bệnh khác nhau dẫn đến bệnh lý FUO này, nên tiên lượng lệ thuộc vào từng trường hợp cụ thể.Nếu sau 6-12 tháng không có chẩn đoán nào gih nhận thì cơ hội giảm rất khó. Tuy nhiên, rất may là tình huống FUO hầu như tiên lượng tốt. Dưới đây là một số nghiên cứu để giúp đồng nghiệp đánh giá lâm sàng trước một ca bệnh đặc biệt như thế nào thoe các chuyên gia trên thế giới ghi nhận và tổng hợp.
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Fever of unknown origin: analysis of 71 consecutive cases.
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Fever of unknown origin in older adults.
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Major causes of fever of unknown origin at Peking Union Medical College Hospital in the past 26 years.
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An analysis of fever of unknown origin defined by newly proposed practical criteria. A prospective study of 56 cases.
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Cervico-mediastinal tuberculous lymphadenitis presenting as prolonged fever of unknown origin.
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The dilemma of diagnosing fever of unknown origin: large arteries vasculitis revealed by 18F-FDG PET/CT imaging. A case report.
De Giorgi A, Fabbian F, Pala M, Bagnari V, Tiseo R, Molino C, Trapassi MR, Boccafogli A, Portaluppi F, Prandini N, Feggi L, Manfredini R.Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1227-30.PMID:22165688Similar articlesSelect item 235871497.
A retrospective study of hospitalized patients with fever of unknown origin (FUO) past six years.
Fukuhara H, Tamaki K, Nakamura H, Kanesima H, Irabu Y, Shimozi K, Kitsukawa K, Shigeno Y, Kyinjou F, Saito A.Kansenshogaku Zasshi. 1990 Mar;64(3):335-41. PMID:2358714Similar articles Select item 2967925398.
Fever of unknown origin (FUO): CMV infectious mononucleosis or lymphoma?
Cunha BA, Chawla K.Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1373-1376. PMID:29679253Similar articles Select item 1670890199.
Classical fever of unknown origin (FUO): current causes in Mexico.
Arce-Salinas CA, Morales-Velázquez JL, Villaseñor-Ovies P, Muro-Cruz D.Rev Invest Clin. 2005 Nov-Dec;57(6):762-9.PMID:16708901Similar articles Select item 29901588100.
Clinical analysis of 215 consecutive cases with fever of unknown origin: A cohort study.
Zhai YZ, Chen X, Liu X, Zhang ZQ, Xiao HJ, Liu G.Medicine (Baltimore). 2018 Jun;97(24):e10986. PMID:29901588Free PMC Article. Similar articles
Fever of unknown origin: a diagnostic approach to this vexing problem.
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A rare case of fever of unknown origin: inflammatory myofibroblastic tumor of the liver. Case report and review of the literature.
Kruth J, Michaely H, Trunk M, Niedergethmann M, Rupf AK, Krämer BK, Göttmann U.Acta Gastroenterol Belg. 2012 Dec;75(4):448-53.PMID:23402091Similar articlesSelect item 27156824103.
Applications of PET/CT in Pediatric Patients with Fever of Unknown Origin.
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Carcinoma of colon presenting as fever of unknown origin.
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Comparison of classical diagnostic criteria and Chinese revised diagnostic criteria for fever of unknown origin in Chinese patients.
Li JJ, Huang WX, Shi ZY, Sun Q, Xin XJ, Zhao JQ, Yin Z.Ther Clin Risk Manag. 2016 Oct 12;12:1545-1551. eCollection 2016.PMID:27785042Free PMC ArticleSimilar articlesSelect item 30153813106.
Delayed diagnosis of extrapulmonary tuberculosis presenting as fever of unknown origin in an intermediate-burden country.
Kim JH, Kim ES, Jun KI, Jung HG, Bang JH, Choe PG, Park WB, Song KH, Kim HB, Kim NJ, Oh MD, Park SW.BMC Infect Dis. 2018 Aug 28;18(1):426. PMID:30153813Free PMC ArticleSimilar articles Select item 26031983107.
Malignant causes of fever of unknown origin.
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Recurrent FUO due to intermittent Enterobacter cloacae bacteremias from an infected pacemaker lead diagnosed by gallium scan.
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Primary antiphospholipid syndrome: a cause of fever of unknown origin.
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Long-term prognosis, treatment, and outcome of patients with fever of unknown origin in whom no diagnosis was made despite extensive investigation: A questionnaire based study.
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Aetiology and management of children with acute fever of unknown origin.
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[Autoinflammatory Diseases as a Differential Diagnosis of Fever of Unknown Origin].
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Fever of unknown origin in children: a systematic review.
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Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005-2015 systematic review.
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Carcinoma of Colon: a rare cause of fever of unknown origin.
Dai W, Chung KS.Chin J Cancer Res. 2012 Jun;24(2):157-60. PMID:23359772Free PMC ArticleSimilar articles Select item 18975488119.
Fever of unknown origin.
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Pyrexia of unknown origin.
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[Paniculitis as manifestation of prolonged febrile syndrome: Case report].
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Fever of unknown origin in gastroenterology.
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INTERLEUKIN-6-PRODUCING PHEOCHROMOCYTOMA AS A NEW REASON FOR FEVER OF UNKNOWN ORIGIN: A RETROSPECTIVE STUDY.
Cheng X, Zhang M, Xiao Y, Li H, Zhang Y, Ji Z.Endocr Pract. 2018 Jun;24(6):507-511. doi: 10.4158/EP-2018-0048. Epub 2018 Apr 6.PMID:29624096Similar articlesSelect item 8272929124.
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Current challenges in the diagnosis and management of fever.
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Clinical value of gallium-67 scintigraphy in evaluation of fever of unknown origin.
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Fever of unknown origin and Q-fever: a case series in a Bulgarian hospital.
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Fever of unknown origin in malignancies.
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Clinical Etiologies of Fever of Unknown Origin in 500 Cases.
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Establishment of a Predictive Model Related to Pathogen Invasion for Infectious Diseases and Its Diagnostic Value in Fever of Unknown Origin.
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Lessons learned from splenic infarcts with fever of unknown origin (FUO): culture-negative endocarditis (CNE) or malignancy?
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Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children.
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Intra-cardiac thrombus in antiphospholipid antibody syndrome: An unusual cause of fever of unknown origin with review of literature.
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A woman in her thirties with fever of unknown origin.
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Long-term outcome of patients discharged with fever of unknown origin in the Department of General Internal Medicine of Peking Union Medical College Hospital.
Li Y, Zhu W, Wang Y, Sha Y, Huang X, Huang C, Jiao Y, Chen J, Fang W, Zeng X.Zhonghua Nei Ke Za Zhi. 2015 Oct;54(10):851-4. PMID:26675023Similar articlesSelect item 28357088144.
Fever of unknown origin revealed to be primary splenic lymphoma: A rare case report with review of the literature.
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[Prolonged fever of unknown origin: the point of view of the rheumatologist].
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Molecular diagnostics in FUO.
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Etiological Distribution and Clinical Features of Fever of Unknown Origin with Pulmonary Lesions in South China.
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Fever in Cancer Patients.
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Economicalness of outpatient laboratory diagnostics.
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Etiology of Classic Fever of Unknown Origin (FUO) among Immunocompetent Indian Adults.
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High fever (greater than 39 degrees C) as a clinical manifestation of pulmonary embolism.
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Fever of unknown origin: a retrospective review of pediatric patients from an urban, tertiary care center in Washington, DC.
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Persistent fever in the travelling child].
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A complex case of sarcoidosis fever.
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Fever of Unknown Origin as a Sole Presentation of Subacute Thyroiditis in an Elderly Patient: A Case Report with Literature Review.
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Consider further differential diagnoses.
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Additional comments regarding diagnosis and treatment.
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Fever of unknown origin.
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Response to Jolobe: 'Molecular diagnostics in FUO'.
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In reply.
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Do not administer free glucose solution.
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Laboratory tests are important.
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Pointers for the examination technique.
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Fever of unknown origin caused by infectious diseases in the era of migrant and refugee crisis.
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Key diagnostic features of fever of unknown origin: Medical history and physical findings.
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Primary bone marrow lymphoma: A hematological emergency in adults with fever of unknown origin.
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The complaint of persistent fever. Recognition and management of pseudo fever of unknown origin.
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[Persistent fever for more than 10 days in a urological patient].
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Detection of human herpesviruses (HHVs) DNA in blood samples: a true marker of Fever of Unknown Origin (FUO)?
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[Programs for Continuing Medical Education: A session; 7. Differential diagnosis of unknown fever for physician].
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Reply to "Detection of human herpesviruses (HHVs) DNA in blood samples: a true marker of Fever of Unknown Origin (FUO)?".
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Fever of unknown origin due to dental infections: cases report and review.
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Primary hyperparathyroidism presenting as fever of unknown origin with unremitting headache.
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[Muscle tissue lymphoma presenting only with fever of unknown origin: a case report and literature review].
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A Toddler With Prolonged Fever and Intermittent Cough.
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Fever of unknown origin; final diagnosis and natural history.
BLOOMFIELD SS.Can Serv Med J. 1955 Sep;11(8):529-33. No abstract available. PMID:13240630Similar articles Select item 27735812198.
Did the child have fever of unknown origin?
Özsoylu Ş.Turk J Pediatr. 2015 Nov-Dec;57(6):648. No abstract available. PMID:27735812Similar articlesSelect item 29237620199.
Is the PET/CT first choice for differential diagnosis of fever of FUO/IUO?
Armagan B, Erden A, Beydas O, Sari A, Kilic L, Kalyoncu U.Ann Rheum Dis. 2018 Nov;77(11):e82. PMID:29237620Similar articlesSelect item 13380527200.
A review of fever of unknown origin.
BERMAN B.Sinai Hosp J (Balt). 1956 Oct;5(2):8-13. No abstract available. PMID:13380527Similar articles
Fever of unknown origin.
BENNETT IL Jr, HOOK EW.Dis Mon. 1957 Nov;7:1-48. No abstract available. PMID:13480073Similar articles Select item 20998225202.
Fever of unknown origin.
ALEXANDER HL, HARFORD CG, et al.Am J Med. 1946 Oct;1:428-36. No abstract available. PMID:20998225Similar articlesSelect item 18107025203.
Fever of unknown origin.
TANDETA M.Clin Proc Child Hosp Dist Columbia. 1948 Oct;4(11):287-91.PMID:18107025Similar articlesSelect item 13313084204.
Fever of unknown origin. II. A discussion around four typical cases.
BOTTIGER LE.Acta Med Scand. 1956 May 3;154(3):215-23. PMID:13313084Similar articlesSelect item 15402994205.
[Fever of unknown origin with severe anemia].
VAN DOMMELEN CK.Ned Tijdschr Geneeskd. 1949 Sep 17;93(38):3266-8. PMID:15402994Similar articlesSelect item 18100398206.
Diabetes, fever of unknown origin and coma.
ALEXANDER HL, SCHROEDER HA, et al.Am J Med. 1948 Dec;5(6):898-907. No abstract available. PMID:18100398Similar articlesSelect item 23390940207.
Sarcoidosis-associated fatigue: an often forgotten symptom.
Kapoor S.Expert Rev Clin Immunol. 2013 Feb;9(2):109-10. PMID:23390940Similar articlesSelect item 28672415208.
[Fever of Unknown Origin].
Märker-Hermann E.Dtsch Med Wochenschr. 2017 Jul;142(13):937. PMID:28672415Similar articlesSelect item 26330471209.
Fever of Unknown Origin: Where Science Meets Art.
Rathore M.Pediatr Rev. 2015 Sep;36(9):378-9.PMID:26330471Similar articlesSelect item 14146950210.
[REFLECTIONS on THE DIFFERENTIAL DIAGNOSIS OF A CASE OF PROLONGED FEVER OF UNDETERMINED ORIGIN].
AGUSTONI CB, PITTELLI JG, D ALTO PA, CERVI RJ.Dia Med. 1964 May 11;36:452-4. Spanish. No abstract available. PMID:14146950Similar articlesSelect item 14251392211.
THE FEVER OF SARCOIDOSIS.
NOLAN JP, KLATSKIN G.Clin Notes Respir Dis. 1965;3:12-3. No abstract available. PMID:14251392Similar articlesSelect item 27181561212.
Should Inflammatory Markers Be Used in the Diagnosis of a Fever of Unknown Origin?
Naito T.Intern Med. 2016;55(10):1407. PMID:27181561Free ArticleSimilar articles Select item 27181560213.
Should Inflammatory Markers Be Used in the Diagnosis of a Fever of Unknown Origin?
Yaita K, Kunimatsu J.Intern Med. 2016;55(10):1405. PMID:27181560Free ArticleSimilar articles Select item 17369738214.
Inflammatory pseudotumor: An unusual cause of fever of unknown origin.
Al-Ansari H, Novelli V.Ann Saudi Med. 1997 May;17(3):344-6. No abstract available. PMID:17369738Free ArticleSimilar articlesSelect item 29557188215.
An 8-Year-Old Male With Fever of Unknown Origin.
Glinton KE, Sharp EA, Mendelsohn MJ.Clin Pediatr (Phila). 2018 Sep;57(10):1239-1242. PMID:29557188Similar articlesSelect item 29518869216.
A disease that is easily overlooked in elderly patients with fever of unknown origin.
Zhang Y, Zeng XJ.Zhonghua Nei Ke Za Zhi. 2018 Mar 1;57(3):221-222. No abstract available. PMID:29518869Similar articlesSelect item 24510932217.
Fever of unknown origin: the naming of uncertainty.
Nazario RJ.Hosp Pediatr. 2011 Jul 1;1(1):62-4. available. PMID:24510932Free ArticleSimilar articlesSelect item 15416629218.
The problem of fever of obscure origin.
PLASS JB.Mil Surg. 1950 Jun;106(6):469-75. No abstract available. PMID:15416629Similar articlesSelect item 30099866219.
Fever of unknown origin caused by intrathyroidal thymic carcinoma.
Chung SM, Kim KJ, Moon JS, Hong YH, Kang SH.Korean J Intern Med. 2019 May;34(3):683-684. doi: 10.3904/kjim.2017.340. Epub 2018 Aug 13. No abstract available. PMID:30099866Free PMC ArticleSimilar articles Select item 13929261220.
[Prolonged fever (examples of diagnostic difficulties)].
LEFKOWITZ M, GUTMAN A.Dapim Refuiim. 1963 May;22:225-8. Hebrew. No abstract available. PMID:13929261Similar articles
To tilfelle av febris causa ignotae.
SALVESENS HA.Tidsskr Nor Laegeforen. 1947 Feb 15;67(4):92. Undetermined Language. No abstract available. PMID:20296970Similar articlesSelect item 29917815222.
Observations upon the Origin and Latent Period of Fever.
[No authors listed]Med Chir Rev. 1828 Jan 1;8(15):55-66. Review. No abstract available. PMID:29917815Free PMC ArticleSimilar articlesSelect item 29419015223.
The Nature and Origin of Climatic Fever.
Oldham CF.Trans Epidemiol Soc Lond. 1882;4(Pt 4):564-579. No abstract available. PMID:29419015Free PMC ArticleSimilar articlesSelect item 31130333224.
Fever of un-Swiss origin.
Lebowitz D, Celi L, Tshikung on, Starobinski M, Chappuis F, Serratrice J.Presse Med. 2019 Jun;48(6):740-744. PMID:31130333Similar articlesSelect item 29007307225.
A Case for Diagnosis: A Developmental Defect of Unknown Origin.
Noronha AJ.Ind Med Gaz. 1921 Jan;56(1):10-13. No abstract available. PMID:29007307Free PMC ArticleSimilar articlesSelect item 10806515226.
Unknown case
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