Primaquine, an 8-aminoquinoline drug capable of clearing the intra-hepatic schizonts, hypnozoites of Plasmodium vivax, and holds a unique and unreplaceable radical cure, but the non-compliance with 14 day-course primaquine regimen is a big problem now.
Malaria is a vector-borne disease by far the world's most important tropical parasitic disease with high mortality and morbidity, especially in tropical Africa and South East Asia. The emergence of artemisinin resistance in Vietnam as big obstacle to reduce the malaria burden and elimination.
A recent letter published in The Lancet Infectious Diseases1 reported on the presence of a drug-resistant lineage (strain) of malaria parasites in south Viet Nam that is responsible for "alarming rates of failure" of dihydroartemisinin-piperaquine, a first-line antimalarial medicine. The lineage, first identified in Cambodia in 2008, has now become the dominant lineage in some parts of the region. This letter builds on data published earlier in the year.