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Cập nhật tài liệu nghiên cứu liên quan amip gây bệnh lý não và màng não trên thế giới (1960 – 2014)

Viêm não màng não do amip là một nhiễm trùng hệ thần kinh trung ương rất hiếm gặp và thường xuất hiện rải rác, do tác nhân các amip sống tự do, đặc biệt Naegleria fowleri và Balamuthia mandrillaris, cũng như loài AcanthamoebaSappinia. Các tài liệu tổng hợp và cập nhật thông tin về bệnh lý mới viêm não màng não do tác nhân amip là mối đe dọa mới với sức khỏe con người

Điển hình, N. fowleri gây ra các ca viêm não màng não do amip tiên phát (primary amebic meningoencephalitis_PAM) và các loài amip khác gây viêm não dạng u hạt (granulomatous amebic encephalitis_GAE) mà lâm sàng khó có thể phân biệt với viêm não màng não do virus hoặc vi khuẩn và hầu như các ca đều tử vong. Tại Việt Nam, gần đây trong Hội thảo về các bệnh nhiễm trùng đang nổi có báo cáo hai ca bệnh (1 bệnh nhân nam 23 tuổi và 1 trẻ em 6 tuổi có yếu tố dịch tễ). Nhân đây, chúng tôi mong muốn tổng hợp và cập nhật thông tin về bệnh lý mới viêm não màng não do tác nhân amip, như một mối đe dọa mới đang nhiễm ở loài người.

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114.Yoder JS, Hlavsa MC, Craun GF, et al. Surveillance for waterborne disease and outbreaks associated with recreational water use and other aquatic facility-associated health events--United States, 2005-2006. MMWR Surveill Summ. Sep 12 2008;57(9):1-29. [Medline].

115.Marciano-Cabral F, Cabral G. The immune response to Naegleria fowleri amebae and pathogenesis of infection. FEMS Immunol Med Microbiol. 2007;51:243-59.

116.Healthbeat 2013, Brain-eating warning after Naegleria fowleri amoeba affects 2nd child

117.Marc Lallanilla (2013), Brain-Eating Amoeba Infects 12-Year-Old Girl, http://www.livescience.com

118.Visvesvara GS. Free-living amebae as opportunistic agents of human disease.  [PDF - 13 pages] J Neuroparasitol. 2010;1.

119.Yoder JS, Eddy BA, Visvesvara GS, Capewell L, Beach MJ. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008. Epidemiol Infect. 2010;138:968-75.

120.Seidel J, Harmatz P, Visvesvara GS, Cohen A, Edwards J, Turner J. Successful treatment of primary amebic meningoencephalitis. New Engl J Med. 1982;306:346-8.

121.Vargas-Zepeda J, Gomez-Alcala AV, Vasquez-Morales JA, Licea-Amaya L, De Jonckheere JF, Lores-Villa F. Successful treatment of Naegleria PAM using IV amphotericin B, fluconazole, and rifampin. Arch Med Res. 2005;36:83-6.

122.John DT, John RA. Cytopathogenicity of Naegleria fowleri in mammalian cell cultures. Parasitol Res. 1989;76:20-5.

123.Marciano-Cabral F, Cabral G. The immune response to Naegleria fowleri amebae and pathogenesis of infection. FEMS Immunol Med Microbiol. 2007;51:243-59.

124.Visvesvara GS. Free-living amebae as opportunistic agents of human disease.  [PDF - 13 pages] J Neuroparasitol. 2010;1.

125.Yoder JS, Eddy BA, Visvesvara GS, Capewell L, Beach MJ. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008. Epidemiol Infect. 2010;138:968-75.

126.Fowler M, Carter RF. Acute pyogenic meningitis probably due to Acanthamoeba sp.: a preliminary report.  [PDF - 4 pages] Br Med J. 1965;2:740-2.

127.Butt CG. Primary amebic meningoencephalitis. N Engl J Med. 1966;274:1473-6.

128.Gustavo dos Santos Neto. Fatal primary amebic meningoencephalitis. A retrospective study in Richmond, Virginia. Am J Clin Pathol. 1970;54:737-42.

129.Visvesvara G, Yoder J, Beach MJ. (2012) Primary amebic meningoencephalitis Chapter 73, pgs 442-447. In: Netter's Infectious Diseases, Eds. Yong EC, Stevens DL. Elsevier Saunders. Philadelphia, PA.

130.Visvesvara GS, Moura H, Schuster FL. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol Med Microbiol. 2007;50:1-26.

131.Chang SL. Resistance of pathogenic Naegleria to some common physical and chemical agents.  [PDF - 8 pages] Appl Environ Microbiol. 1978;35:368-75.

132.Griffin JL. Temperature tolerance of pathogenic and nonpathogenic free-living amoebas. Science.1972;178(63):869-70.

133.Tiewchaloren S, Junnu V. Factors affecting the viability of pathogenic Naegleria species isolated from Thai patients.  [PDF - 7 pages] J Trop Med Parasitol. 1999;22:15-21.

134.De Jonckheere J, van de Voorde H. Differences in destruction of cysts of pathogenic and nonpathogenic Naegleria and Acanthamoeba by chlorine.   [PDF - 4 pages] Appl Environ Microbiol. 1976;31:294-7. (1mg/l for an hour for cysts)

135.Cursons RT, Brown TJ, Keys EA. Effect of disinfectants o­n pathogenic free-living amoebae: in axenic conditions.  [PDF - 5 pages] Appl Environ Microbiol. 1980;40:62-6.

136.Robinson BS, Christy PE. Disinfection of water for control of amoebae. Water. 1984;September:21-4.

137.Sarkar P, Gerba C. Inactivation of Naegleria fowleri by chlorine and ultraviolet light. J AWWA. 2012;104:51-2.

138.Jarroll EL, Bingham AK, Meyer EA. Effect of chlorine o­n Giardia lamblia cyst viability.   [PDF - 5 pages] Appl Environ Microbiol. 1981;41:483-7.

139.Rice EW, Hoff JC, Schaefer FW 3rd. Inactivation of Giardia cysts by chlorine.   [PDF - 2 pages] Appl Environ Microbiol. 1982;43:250-1.

140.Marciano-Cabral F, Cabral G. The immune response to Naegleria fowleri amebae and pathogenesis of infection. FEMS Immunol Med Microbiol.2007;51:243-59.

141.Visvesvara GS. Free-living amebae as opportunistic agents of human disease.  [PDF - 13 pages] J Neuroparasitol. 2010;1.

142.Yoder JS, Eddy BA, Visvesvara GS, Capewell L, Beach MJ. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008. Epidemiol Infect. 2010;138:968-75.

143.Griffin JL. Temperature tolerance of pathogenic and nonpathogenic free-living amoebas. Science. 1972;178(63):869-70.

144.Chang SL. Resistance of pathogenic Naegleria to some common physical and chemical agents.  [PDF - 8 pages] Appl Environ Microbiol. 1978;35:368-75.

145.Maclean RC, Richardson DJ, LePardo R, Marciano-Cabral F. The identification of Naegleria fowleri from water and soil samples by nested PCR. Parasitol Res 2004;93: 211–17.

146.Wellings FM, Amuso PT, Chang SL, Lewis AL. Isolation and identification of pathogenic Naegleria from Florida lakes. Appl Environ Microbiol 1977;34:661–7.

147.John DT, Howard MJ. Seasonal distribution of pathogenic free-living amebae in Oklahoma waters. Parasitol Res 1995;81:193–201.

148.Duma RJ. Study of pathogenic free-living amebas in fresh-water lakes in Virginia. EPA Publication. 1980;EPA-PB-126369, Summary, 1981 is EPA-600/S1-80-037.

149.Ettinger MR, Webb SR, Harris SA, McIninch SP, C Garman G, Brown BL. Distribution of free-living amoebae in James River, Virginia, USA. Parasitol Res. 2003;89:6-15.

150.Sheehan KB, Fagg JA, Ferris MJ, Henson JM. PCR detection and analysis of the free-living amoeba Naegleria in hot springs in Yellowstone and Grand Teton National Parks. Appl Environ Microbiol. 2003;69:5914-8.

151.Sykora JK, Keleti G, Martinez AJ. Occurrence and pathogenicity of Naegleria fowleri in artificially heated waters. Appl and Envion Microbiol. 1983;45:974-9.

152.Stevens AR, Tyndall RL, Coutant CC, Willaert E. Isolation of the etiological agent of primary amoebic meningoencephalitis from artificially heated waters. Appl Environ Microbiol. 1977;34(6):701-5.

153.Marciano-Cabral F, MacLean R, Mensah A, LaPat-Polasko L. Identification of Naegleria fowleri in domestic water sources by nested PCR. Appl Environ Microbiol. 2003;69:5864-9.

154.Blair B, Sarkar P, Bright KR, Marciano-Cabral F, Gerba CP. Naegleria fowleri in well water. Emerg Infect Dis. 2008;14:1499-501.

155.Yoder JS, Straif-Bourgeois S, Roy SL, Moore TA, Visvesvara GS, Ratard RC, Hill V, Wilson JD, Linscott AJ, Crager R, Kozak NA, Sriram R, Narayanan J, Mull B, Kahler AM, Schneeberger C, da Silva AJ, Beach MJ. Deaths from Naegleria fowleri associated with sinus irrigation with tap water: a review of the changing epidemiology of primary amebic meningoencephalitis. Clin Infect Dis. 2012;1-7.

156.Kemble SK, Lynfield R, DeVries AS, Drehner DM, Pomputius WF 3rd, Beach MJ, Visvesvara GS, da Silva AJ, Hill VR, Yoder JS, Xiao L, Smith KE, Danila R. Fatal Naegleria fowleri infection acquired in Minnesota: possible expanded range of a deadly thermophilic organism. Clin Infect Dis. 2012;54:805-9.

157.Anderson K, Jamieson A. Primary amoebic meningoencephalitis. Lancet. 1972;1:902–3.

158.Dorsch MM, Cameron AS, Robinson BS. The epidemiology and control of primary amoebic meningoencephalitis with particular reference to South Australia. Trans R Soc Trop Med Hyg. 1983;77:372-7.

159.Puzon GJ, Lancaster JA, Wylie JT, Plumb IJ. Rapid detection of Naegleria fowleri in water distribution pipeline biofilms and drinking water samples. Environ Sci Technol. 2009;43:6691-6.

160.Shakoor S, Beg MA, Mahmood SF, Bandea R, Sriram R, Noman F, et al. Primary amebic meningoencephalitis caused by Naegleria fowleri, Karachi, Pakistan.   [PDF - 4 pages] Emerg Infect Dis 2011:17;258-61.

161.Gustavo dos Santos Neto. Fatal primary amebic meningoencephalitis. A retrospective study in Richmond, Virginia. Am J Clin Pathol. 1970;54:737-42.

162.Kramer MH, Lerner CJ, Visvesvara GS. Kidney and liver transplants from a donor infected with Naegleria fowleri. J Clin Microbiol. 1997;35:1032-3.

163.Bennett WM, Nespral JF, Rosson MW, McEvoy KM. Use of organs for transplantation from a donor with primary meningoencephalitis due to Naegleria fowleri. Am J Transplant. 2008;8:1334-5.

164.Tuppeny M. Primary amoebic meningoencephalitis with subsequent organ procurement: a case study. J Neurosci Nurs. 2011;43:274-9.

165.Visvesvara GS, De Jonckheere JF, Sriram R, Daft B.Isolation and molecular typing of Naegleria fowleri from the brain of a cow that died of primary amebic meningoencephalitis. J Clin Microbiol. 2005;43:4203-4.

166.Lozano-Alarcón F, Bradley GA, Houser BS, Visvesvara GS. Primary amebic meningoencephalitis due to Naegleria fowleri in a South American tapir. Vet Pathol. 1997;34:239-43.

167.John DT, Nussbaum SL. Naegleria fowleri infection acquired by mice through swimming in amebae-contaminated water. J Parasitol. 1983;69:871-4.

168.US Census Bureau. Statistical Abstract of the United States: 2012. Arts, Recreation, and Travel: Participation in Selected Sports Activities 2009.   [PDF - 2 pages]

169.Cabanes PA, Wallet F, Pringuez E, Pernin P. Assessing the risk of primary amoebic meningoencephalitis from swimming in the presence of environmental Naegleria fowleri. Appl Environ Microbiol. 2001;67:2927-31.

170.Marciano-Cabral F, Cabral G. The immune response to Naegleria fowleri amebae and pathogenesis of infection. FEMS Immunol Med Microbiol. 2007;51:243-59.

171.Visvesvara GS. Free-living amebae as opportunistic agents of human disease.  [PDF - 13 pages] J Neuroparasitol. 2010;1.

172.Council for State and Territorial Epidemiologists (CSTE). Case Definitions for Non-notifiable Infections Caused by Free-living Amebae (Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba spp.)  [PDF - 10 pages]. Infectious Disease Committee. 2012.

173.Visvesvara GS. Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment. Curr Opin Infect Dis. 2010;23(6):590-4.

174.da Rocha-Azevedo B, Tanowitz HB, Marciano-Cabral F. Diagnosis of infections caused by pathogenic free-living amoebae. Interdiscip Perspect Infect Dis. 2009;2009:251406.

175.Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol. 2006;44(10):3589-95.

176.Robinson BS, Monis PT, Dobson PJ. Rapid, sensitive, and discriminating identification of Naegleria spp. by real-time PCR and melting-curve analysis. Appl Environ Microbiol. 2006;72(9):5857-63.

177.Marciano-Cabral F, MacLean R, Mensah A, LaPat-Polasko L. Identification of Naegleria fowleri in domestic water sources by nested PCR. Appl Environ Microbiol. 2003;69:5864-9.

178.Visvesvara GS. Parasite Culture: Acanthamoeba and Naegleria spp. In: Garcia LS, editor. Clinical Microbiology Procedures Handbook. 3rd ed. Washington, DC: ASM Press; 2010.

179.Yoder JS, Eddy BA, Visvesvara GS, Capewell L, Beach MJ. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008. Epidemiol Infect. 2010;138:968-75.

180.Seidel JS, Harmatz P, Visvesvara GS, Cohen A, Edwards J, Turner J. Successful treatment of primary amebic meningoencephalitis. N Engl J Med. 1982;306:346-8.

181.Visvesvara GS, Moura H, Schuster FL. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol Med Microbiol. 2007;50:1-26.

182.Vargas-Zepeda J, Gomez-Alcala AV, Vasquez-Morales JA, Licea-Amaya L, De Jonckheere JF, Lores-Villa F. Successful treatment of Naegleria PAM using IV amphotericin B, fluconazole, and rifampin. Arch Med Res. 2005;36:83-6.

183.John DT, John RA. Cytopathogenicity of Naegleria fowleri in mammalian cell cultures. Parasitol Res. 1989;76:20-5.

184.Visvesvara GS. Free-living amebae as opportunistic agents of human disease.  [PDF - 13 pages] J Neuroparasitol. 2010;1.

185.Visvesvara GS, Moura H, Schuster FL. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol and Med Microbiol. 2007;50:1–26.

186.Visvesvara GS. Pathogenic and Opportunistic Amebae. Manual of Clinical Microbiology, 9th ed. Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA, editors. Washington DC: ASM Press. 2007. p. 2082-91.

187.Marciano-Cabral F, Cabral G. Acanthamoeba spp. as agents of disease in humans. Clin Microbiol Rev. 2003;16:273-307.

188.Hlavsa MC, Roberts VA, Anderson AR, Hill VR, Kahler AM, Orr M, Garrison LE, Hicks LA, Newton A, Hilborn ED, Wade TJ, Beach MJ, Yoder JS. Surveillance for waterborne disease outbreaks and other health events associated with recreational water use — United States, 2007–2008.MMWR Surveill Summ. 2011;60:1-37.

189.Yoder JS, Eddy BA, Visvesvara GS, Capewell L, Beach MJ. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008. Epidemiol Infect. 2010;138:968-75.

190.Yoder J, Hlavsa M, Craun GF, Hill V, Roberts V, Yu P, Hicks LA, Alexander NT, Calderon RL, Roy SL, Beach MJ. (2008) Surveillance for waterborne disease and outbreaks associated with recreational water use and other aquatic facility-associated health events — United States, 2005–2006.  [PDF - 72 pages] MMWR Surveill Summ. 57:1-38.

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192.Yoder JS, Straif-Bourgeois S, Roy SL, Moore TA, Visvesvara GS, Ratard RC, Hill V, Wilson JD, Linscott AJ, Crager R, Kozak NA, Sriram R, Narayanan J, Mull B, Kahler AM, Schneeberger C, da Silva AJ, Beach MJ. Deaths from Naegleria fowleri associated with sinus irrigation with tap water: a review of the changing epidemiology of primary amebic meningoencephalitis. Clin Infect Dis. 2012;1-7.

193.Kemble SK, Lynfield R, DeVries AS, Drehner DM, Pomputius WF 3rd, Beach MJ, Visvesvara GS, da Silva AJ, Hill VR, Yoder JS, Xiao L, Smith KE, Danila R. Fatal Naegleria fowleri infection acquired in Minnesota: possible expanded range of a deadly thermophilic organism. Clin Infect Dis. 2012;54:805-9.

194.Tuppeny M. Primary amoebic meningoencephalitis with subsequent organ procurement: a case study. J Neurosci Nurs. 2011;43:274-9.

195.Yoder JS, Eddy BA, Visvesvara GS, Capewell L, Beach MJ. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008. Epidemiol Infect. 2010;138:968-75.

196.Puzon GJ, Lancaster JA, Wylie JT, Plumb IJ. Rapid detection of Naegleria fowleri in water distribution pipeline biofilms and drinking water samples. Environ Sci Technol. 2009;43:6691-6.

197.US Census Bureau. Statistical Abstract of the United States: 2012. Arts, Recreation, and Travel: Participation in Selected Sports Activities 2009.   [PDF - 2 pages]

198.Bennett WM, Nespral JF, Rosson MW, McEvoy KM. Use of organs for transplantation from a donor with primary meningoencephalitis due to Naegleria fowleri. Am J Transplant. 2008;8:1334-5.

199.Blair B, Sarkar P, Bright KR, Marciano-Cabral F, Gerba CP. Naegleria fowleri in well water. Emerg Infect Dis. 2008;14:1499-501.

200.Visvesvara GS, De Jonckheere JF, Sriram R, Daft B. Isolation and molecular typing of Naegleria fowleri from the brain of a cow that died of primary amebic meningoencephalitis. J Clin Microbiol. 2005;43:4203-4.

201.Maclean RC, et al. The identification of Naegleria fowleri from water and soil samples by nested PCR. Parasitol Res 2004;93:211–7.

202.Ettinger MR, Webb SR, Harris SA, McIninch SP, C Garman G, Brown BL. Distribution of free-living amoebae in James River, Virginia, USA. Parasitol Res. 2003;89:6-15.

203.Sheehan KB, Fagg JA, Ferris MJ, Henson JM. PCR detection and analysis of the free-living amoeba Naegleria in hot springs in Yellowstone and Grand Teton National Parks. Appl Environ Microbiol. 2003;69:5914-8.

204.Cabanes PA, Wallet F, Pringuez E, Pernin P. Assessing the risk of primary amoebic meningoencephalitis from swimming in the presence of environmental Naegleria fowleri. Appl Environ Microbiol. 2001;67:2927-31.

205.John DT, Howard MJ. Seasonal distribution of pathogenic free-living amebae in Oklahoma waters. Parasitol Res 1995;81:193–201.

206.Dorsch MM, Cameron AS, Robinson BS. The epidemiology and control of primary amoebic meningoencephalitis with particular reference to South Australia. Trans R Soc Trop Med Hyg. 1983;77:372-7.

207.John DT, Nussbaum SL. Naegleria fowleri infection acquired by mice through swimming in amebae-contaminated water. J Parasitol. 1983;69:871-4.

208.Sykora JK, Keleti G, Martinez AJ. Occurrence and pathogenicity of Naegleria fowleri in artificially heated waters. Appl and Envion Microbiol. 1983;45:974-9.

209.Duma RJ. Study of pathogenic free-living amebas in fresh-water lakes in Virginia. EPA Publication. 1980;EPA-PB-126369, Summary, 1981 is EPA-600/S1-80-037.

210.Wellings FM, et al. Isolation and identification of pathogenic Naegleria from Florida lakes. Appl Environ Microbiol 1977;34:661–7.

211.Stevens AR, Tyndall RL, Coutant CC, Willaert E. Isolation of the etiological agent of primary amoebic meningoencephalitis from artificially heated waters. Appl Environ Microbiol. 1977;34(6):701-5.

212.Griffin JL. Temperature tolerance of pathogenic and nonpathogenic free-living amoebas. Science. 1972;178(63):869-70.

213.Anderson K, Jamieson A. Primary amoebic meningoencephalitis. Lancet. 1972;1:902–3.

214.Gustavo dos Santos Neto. Fatal primary amebic meningoencephalitis. A retrospective study in Richmond, Virginia. Am J Clin Pathol. 1970;54:737-42.

215.Visvesvara GS. Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment. Curr Opin Infect Dis. 2010 Dec;23(6):590-4.

216.Visvesvara GS. Parasite Culture: Acanthamoeba and Naegleria spp. In: Garcia LS, editor. Clinical Microbiology Procedures Handbook. 3rd ed. Washington, DC: ASM Press;2010.

217.da Rocha-Azevedo B, Tanowitz HB, Marciano-Cabral F. Diagnosis of infections caused by pathogenic free-living amoebae. Interdiscip Perspect Infect Dis. 2009;2009:251406.

218.Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol. 2006;44(10):3589-95.

219.Robinson BS, Monis PT, Dobson PJ. Rapid, sensitive, and discriminating identification of Naegleria spp. by real-time PCR and melting-curve analysis. Appl Environ Microbiol. 2006;72(9):5857-63.

220.Marciano-Cabral F, MacLean R, Mensah A, LaPat-Polasko L. Identification of Naegleria fowleri in domestic water sources by nested PCR. Appl Environ Microbiol. 2003;69:5864-9.

221.Marciano-Cabral F, MacLean R, Mensah A, LaPat-Polasko L. Identification of Naegleria fowleri in domestic water sources by nested PCR. Appl Environ Microbiol. 2003;69:5864-9.

222.Martínez DY, Seas C, Bravo F, Legua P, Ramos C, Cabello AM, Gotuzzo E. Successful treatment of Balamuthia mandrillaris amoebic infection with extensive neurological and cutaneous involvement. Clin Infect Dis. 2010;51:e7-11.

223.Walochnik J, Obwaller A, Gruber F, Mildner M, Tschachler E, Suchomel M, Duchene M, Auer H. Anti-Acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent. J Antimicrob Chemother. 2009;64:539-45.

224.Kim JH, Jung SY, Lee YJ, Song KJ, Kwon D, Kim K, Park S, Im KI, Shin HJ. Effect of therapeutic chemical agents in vitro and o­n experimental meningoencephalitis due to Naegleria fowleri.  [PDF - 7 pages] Antimicrob Agents Chemother. 2008;52:4010-6.

225.Aichelburg AC, Walochnik J, Assadian O, Prosch H, Steuer A, Perneczky G, Visvesvara GS, Aspöck H, Vetter N. Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine.   [PDF - 4 pages] Emerg Infect Dis. 2008;14:1743-6.

226.Soltow SM, Brenner GM. Synergistic activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.  [PDF - 5 pages] Antimicrob Agents Chemother. 2007;51:23–7.

227.Schuster FL, Guglielmo BJ, Visvesvara GS. In-vitro activity of miltefosine and voriconazole o­n clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri. J Eukaryot Microbiol. 2006;53:121-6.

228.Vargas-Zepeda J, Gomez-Alcala AV, Vasquez-Morales JA, Licea-Amaya L, De Jonckheere JF, Lores-Villa F. Successful treatment of Naegleria PAM using IV amphotericin B, fluconazole, and rifampin. Arch Med Research 2005;36:83-6.

229.Schuster FL, Visvesvara GS. Free-living opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitiol 2004;34:1001-27.

230.Schuster FL, Visvesvara GS. Opportunistic amebae: challenges in prophylaxis and treatment. Drug Resistance Updates 2004;7:41-51.

231.Deetz TR, Sawyer MH, Billman G, Schuster FL, Visvesvara GS. Successful treatment of Balamuthia amebic encephalitis: presentation of 2 cases. Clin Infect Dis 2003;37:1304-12.

232.Goswick SM, Brenner GM. Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.  [PDF - 5 pages] Antimicrob Agents Chemother. 2003;47:524-8.

233.Goswick SM, Brenner GM. Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. J Parasitol. 2003;89:837-42.

234.Jain R, Prabhaker S, Modi M, Bhatia R, Sehgal R. Naegleria meningitis: A rare survival. Neurol India 2002;50:470-2.

235.Kaminsky R. Miltefosine Zentaris. Curr Opin Investig Drugs. 2002;3:550-4.

236.Seidel J, Harmatz P, Visvesvara GS, Cohen A, Edwards J, Turner J. Successful treatment of primary amebic meningoencephalitis. New Engl J Med 1982;306:346-8.

237.Ferrante A. Comparative sensitivity of Naegleria fowleri to amphotericin B and amphotericin B methyl ester. Trans R Soc Trop Med Hyg. 1982;76:476-8.

238.Lee KK, Karr SL Jr, Wong MM, Hoeprich PD. In vitro susceptibilities of Naegleria fowleri strain HB-1 to selected antimicrobial agents, singly and in combination. Antimicrob Agents Chemother. 1979;16:217-20.

239.Kramer MH, Lerner CJ, Visvesvara GS. Kidney and liver transplants from a donor infected with Naegleria fowleri. J Clin Micro 1997 35:1032-3.

240.Sarkar P, Gerba C. Inactivation of Naegleria fowleri by chlorine and ultraviolet light. J AWWA. 2012;104:51-2.

241.Visvesvara G, Yoder J, Beach MJ. (2012) Primary amebic meningoencephalitis Chapter 73, pgs 442-7. In: Netter's Infectious Diseases, Eds. Yong EC, Stevens DL. Elsevier Saunders. Philadelphia, PA.

242.Visvesvara GS, De Jonckheere JF, Sriram R, Daft B. Isolation and molecular typing of Naegleria fowleri from the brain of a cow that died of primary amebic meningoencephalitis. J Clin Microbiol. 2005;43:4203-4.

243.Tiewchaloren S, Junnu V. Factors affecting the viability of pathogenic Naegleria species isolated from Thai patients.  [PDF - 7 pages] J Trop Med Parasitol. 1999;22:15-21.

244.Lozano-Alarcón F, Bradley GA, Houser BS, Visvesvara GS. Primary amebic meningoencephalitis due to Naegleria fowleri in a South American tapir. Vet Pathol. 1997 May;34(3):239-43.

245.John DT, John RA. Cytopathogenicity of Naegleria fowleri in mammalian cell cultures. Parasitol Res. 1989;76:20-5.

246.Robinson BS, Christy PE. Disinfection of water for control of amoebae. Water. 1984;September:21-4.

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