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 Chuyên đề Nghiên cứu lâm sàng & điều trị
Phần 2: Thuốc mới hữu ích trong chiến lược loại trừ sốt rét toàn cầu

Một trong những nghiên cứu được coi là thành tựu quan ttrongj của nền y học thế giới đó là nghiên cứu phát triển thuốc mới thuộc nhóm 8-aminoquinolein loại Tafenoquine (liệu trình 1 ngày) nhằm thay thế cho thuốc primaquine cũng là một đồng phân của chúng trong nhóm bởi nhược điểm của thuốc primaquine phosphate này là dùng thuốc phải dùng nhiều ngày (14 ngày theo khuyến cáo của quốc gia và Tổ chức Y tế thế giới) không thể đạt được sự tuân thủ hết liệu trình của các bệnh nhân.

Điều này sẽ dẫn đến còn tồn tại thể ẩn, thể ngủ trong tế bào gan của các bệnh nhân sốt rét nhiễm P. vivaxP. ovale và có thể xem đây là một trong những thách thức trong lộ trình tiến tới loại trừ sốt rét ở Việt Nam và trên thế giới.

The potential elimination of Plasmodium vivax malaria by relapse treatment: insights from a transmission model and surveillance data from NW India.

Roy M, Bouma MJ, Ionides EL, Dhiman RC, Pascual M.PLoS Negl Trop Dis. 2013;7(1):e1979. doi: 10.1371/journal.pntd.0001979. Epub 2013 Jan 10.PMID: 23326611 Free PMC Article Similar articlesSelect item 2838126194.

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group.

Thriemer K, Ley B, Bobogare A, Dysoley L, Alam MS, Pasaribu AP, Sattabongkot J, Jambert E, Domingo GJ, Commons R, Auburn S, Marfurt J, Devine A, Aktaruzzaman MM, Sohel N, Namgay R, Drukpa T, Sharma SN, Sarawati E, Samad I, Theodora M, Nambanya S, Ounekham S, Mudin RN, Da Thakur G, Makita LS, Deray R, Lee SE, Boaz L, Danansuriya MN, Mudiyanselage SD, Chinanonwait N, Kitchakarn S, Nausien J, Naket E, Duc TN, Do Manh H, Hong YS, Cheng Q, Richards JS, Kusriastuti R, Satyagraha A, Noviyanti R, Ding XC, Khan WA, Swe Phru C, Guoding Z, Qi G, Kaneko A, Miotto O, Nguitragool W, Roobsoong W, Battle K, Howes RE, Roca-Feltrer A, Duparc S, Bhowmick IP, Kenangalem E, Bibit JA, Barry A, Sintasath D, Abeyasinghe R, Sibley CH, McCarthy J, von Seidlein L, Baird JK, Price RN.

Malar J. 2017 Apr 5;16(1):141. doi: 10.1186/s12936-017-1784-1. Review.

PMID: 28381261 Free PMC Article Similar articlesSelect item 2379784395.

An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model.

Jin X, Pybus BS, Marcsisin R, Logan T, Luong TL, Sousa J, Matlock N, Collazo V, Asher C, Carroll D, Olmeda R, Walker LA, Kozar MP, Melendez V.Eur J Drug Metab Pharmacokinet. 2014 Jun;39(2):139-46.PMID: 23797843 Similar articlesSelect item 3056527996.

Association between aripiprazole pharmacokinetics and CYP2D6 phenotypes: A systematic review and meta-analysis.

Zhang X, Xiang Q, Zhao X, Ma L, Cui Y.J Clin Pharm Ther. 2018 Dec 18. doi: 10.1111/jcpt.12780. [Epub ahead of print] Review.PMID: 30565279 Similar articlesSelect item 2718885497.

Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants.

Jin X, Potter B, Luong TL, Nelson J, Vuong C, Potter C, Xie L, Zhang J, Zhang P, Sousa J, Li Q, Pybus BS, Kreishman-Deitrick M, Hickman M, Smith PL, Paris R, Reichard G, Marcsisin SR.Malar J. 2016 May 17;15(1):280. doi: 10.1186/s12936-016-1329-z.PMID: 27188854 Free PMC Article Similar articles Select item 2701647098.

Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art.

Marcsisin SR, Reichard G, Pybus BS.Pharmacol Ther. 2016 May;161:1-10. doi: 10.1016/j.pharmthera.2016.03.011. Epub 2016 Mar 22. Review.PMID: 27016470 Free Article Similar articles Select item 2589181299.

Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax.

Campo B, Vandal O, Wesche DL, Burrows JN.Pathog Glob Health. 2015 May;109(3):107-22. doi: 10.1179/2047773215Y.0000000013. Epub 2015 Apr 18. Review.PMID: 25891812 Free PMC Article Similar articles Select item 30400893100.

Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines.

Berman J, Brown T, Dow G, Toovey S.Malar J. 2018 Nov 6;17(1):407. doi: 10.1186/s12936-018-2555-3. Review.PMID: 30400893 Free PMC Article Similar articles

The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.

Nguyen HQ, Callegari E, Obach RS.Drug Metab Dispos. 2016 Oct;44(10):1569-78. doi: 10.1124/dmd.116.071639. Epub 2016 Jul 20.PMID: 27440861 Similar articles Select item 25759576102.

Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice.

Melariri P, Kalombo L, Nkuna P, Dube A, Hayeshi R, Ogutu B, Gibhard L, deKock C, Smith P, Wiesner L, Swai H.Int J Nanomedicine. 2015 Feb 20;10:1493-503. doi: 10.2147/IJN.S76317. eCollection 2015.PMID: 25759576 Free PMC Article Similar articles Select item 29676238103.

Effect of CYP2D6 Poor Metabolizer Phenotype o­n Stereoselective Nebivolol Pharmacokinetics.

Vieira CP, Neves DV, Coelho EB, Lanchote VL.Drug Metab Lett. 2018;12(1):68-70. doi: 10.2174/1872312812666180420104945.PMID: 29676238 Similar articles Select item 30058787104.

CYP2D6 basic genotyping as a potential tool to improve the antiemetic efficacy of o­ndansetron in prophylaxis of postoperative nausea and vomiting.

Niewiński PA, Wojciechowski R, Śliwiński M, Hurkacz ME, Głowacka K, Orzechowska-Juzwenko K, Wiela-Hojeńska AK.Adv Clin Exp Med. 2018 Nov;27(11):1499-1503. doi: 10.17219/acem/69451.PMID: 30058787 Free Article Similar articles Select item 3542534105.

Pharmacokinetics of primaquine in patients with P. vivax malaria.

Bhatia SC, Saraph YS, Revankar SN, Doshi KJ, Bharucha ED, Desai ND, Vaidya AB, Subrahmanyam D, Gupta KC, Satoskar RS.Eur J Clin Pharmacol. 1986;31(2):205-10. PMID: 3542534 Similar articles Select item 28836792106.

Galactose-Anchored Gelatin Nanoparticles for Primaquine Delivery and Improved Pharmacokinetics: A Biodegradable and Safe Approach for Effective Antiplasmodial Activity against P. falciparum 3D7 and in Vivo Hepatocyte Targeting.

Kumar H, Gothwal A, Khan I, Nakhate KT, Alexander A, Ajazuddin, Singh V, Gupta U.Mol Pharm. 2017 Oct 2;14(10):3356-3369. doi: 10.1021/acs.molpharmaceut.7b00376. Epub 2017 Sep 11.PMID: 28836792 Similar articlesSelect item 24913163107.

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA.Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9.PMID: 24913163 Free PMC Article Similar articles Select item 29510711108.

The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial.

Cheah PY, Steinkamp N, von Seidlein L, Price RN.BMC Med Ethics. 2018 Mar 6;19(1):19. doi: 10.1186/s12910-018-0259-4.PMID: 29510711 Free PMC Article Similar articles Select item 10615272109.

The evolution of tafenoquine--antimalarial for a new millennium?

Peters W.J R Soc Med. 1999 Jul;92(7):345-52. Review. No abstract available. PMID: 10615272 Free PMC Article Similar articles Select item 27721533110.

Evaluation of pharmacokinetics of single-dose chloroquine in malnourished children with malaria- a comparative study with normally nourished children.

Kadam PP, Gogtay NJ, Karande S, Shah V, Thatte UM.Indian J Pharmacol. 2016 Sep-Oct;48(5):498-502.PMID: 27721533 Free PMC Article Similar articles Select item 29869298111.

Application of the Stable Isotope Label Approach in Clinical Development-Supporting Dissolution Specifications for a Commercial Tablet Product with Tafenoquine, a Long Half-life Compound.

Goyal N, Mohamed K, Rolfe K, Sahota S, Ernest T, Duparc S, Taylor M, Casillas L, Koh GCKW.AAPS J. 2018 Jun 4;20(4):74. doi: 10.1208/s12248-018-0234-5.PMID: 29869298 Similar articles Select item 22399238112.

The dopaminergic stabilizer pridopidine is to a major extent N-depropylated by CYP2D6 in humans.

Helldén A, Panagiotidis G, Johansson P, Waters N, Waters S, Tedroff J, Bertilsson L.Eur J Clin Pharmacol. 2012 Sep;68(9):1281-6. doi: 10.1007/s00228-012-1248-z. Epub 2012 Mar 8.PMID: 22399238 Similar articlesSelect item 29317838113.

Primaquine double dose for 7 days is inferior to single-dose treatment for 14 days in preventing Plasmodium vivax recurrent episodes in Suriname.

Mac Donald-Ottevanger MS, Adhin MR, Jitan JK, Bretas G, Vreden SG.Infect Drug Resist. 2017 Dec 20;11:3-8. doi: 10.2147/IDR.S135897. eCollection 2018.PMID: 29317838 Free PMC Article Similar articles Select item 27093859114.

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.PMID: 27093859 Free PMC Article Similar articles Select item 13793053115.

Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report.

ALVING AS, JOHNSON CF, TARLOV AR, BREWER GJ, KELLERMEYER RW, CARSON PE.Bull World Health Organ. 1960;22:621-31.PMID: 13793053 Free PMC Article Similar articles Select item 22144436116.

Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.

Myint HY, Berman J, Walker L, Pybus B, Melendez V, Baird JK, Ohrt C.Am J Trop Med Hyg. 2011 Dec;85(6):1010-4. doi: 10.4269/ajtmh.2011.11-0498. Review.PMID: 22144436 Free PMC Article Similar articles Select item 25295216117.

Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax.

Rajgor DD, Gogtay NJ, Kadam VS, Kocharekar MM, Parulekar MS, Dalvi SS, Vaidya AB, Kshirsagar NA.Malar Res Treat. 2014;2014:347018. doi: 10.1155/2014/347018. Epub 2014 Sep 10.PMID: 25295216 Free PMC Article Similar articles Select item 24360370118.

Single-dose radical cure of Plasmodium vivax: a step closer.

Price RN, Nosten F.Lancet. 2014 Mar 22;383(9922):1020-1. doi: 10.1016/S0140-6736(13)62672-0. Epub 2013 Dec 19. No abstract available. PMID: 24360370 Free PMC Article Similar articles Select item 30706164119.

Effects of MAO-A and CYP450 o­n primaquine metabolism in healthy volunteers.

Ariffin NM, Islahudin F, Kumolosasi E, Makmor-Bakry M.Parasitol Res. 2019 Jan 31. doi: 10.1007/s00436-019-06210-3. [Epub ahead of print]PMID: 30706164 Similar articlesSelect item 29713556120.

Relapsing Malaria: A Case Report of Primaquine Resistance.

Dijanic C, Nickerson J, Shakya S, Dijanic A, Fabbri M.Case Rep Infect Dis. 2018 Mar 11;2018:9720823. doi: 10.1155/2018/9720823. eCollection 2018.PMID: 29713556 Free PMC Article Similar articles

Chloroquine-Primaquine Therapeutic Efficacy, Safety, and Plasma Levels in Patients with Uncomplicated Plasmodium vivax Malaria in a Colombian Pacific Region.

Mesa-Echeverry E, Niebles-Bolívar M, Tobón-Castaño A.Am J Trop Med Hyg. 2019 Jan;100(1):72-77. doi: 10.4269/ajtmh.18-0655.PMID: 30457097 Similar articles Select item 14804087122.

Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report.

Edgcomb jh, arnold j, yount eh jr, alving as, eichelberger l, jeffery gm, eyles d, young md.J Natl Malar Soc. 1950 Dec;9(4):285-92. No abstract available. PMID: 14804087 Similar articles Select item 25385861123.

Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects.

Osorio L, Carter N, Arthur P, Bancone G, Gopalan S, Gupta SK, Noedl H, Kochar SK, Kochar DK, Krudsood S, Lacerda MV, Llanos-Cuentas A, Rueangweerayut R, Srinivasan R, Treiber M, Möhrle JJ, Green J.

Am J Trop Med Hyg. 2015 Jan;92(1):22-7. doi: 10.4269/ajtmh.14-0298. Epub 2014 Nov 10.

PMID: 25385861 Free PMC Article Similar articles Select item 28070879124.

A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications.

Elewa H, Wilby KJ.Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):745-756. doi: 10.1007/s13318-016-0399-1. Review.PMID: 28070879 Similar articlesSelect item 30229442125.

Tafenoquine: First Global Approval.

Frampton JE.Drugs. 2018 Sep;78(14):1517-1523. doi: 10.1007/s40265-018-0979-2.PMID: 30229442 Similar articlesSelect item 30380095126.

Tafenoquine for travelers' malaria: evidence, rationale and recommendations.

Baird JK.J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay110.PMID: 30380095 Free PMC Article Similar articles Select item 28350251127.

Impact of CYP2D6 genotype o­n amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.

Chaudhry M, Alessandrini M, Rademan J, Dodgen TM, Steffens FE, van Zyl DG, Gaedigk A, Pepper MS.Pharmacogenomics. 2017 Apr;18(5):433-443. doi: 10.2217/pgs-2016-0185. Epub 2017 Mar 28.PMID: 28350251 Free Article Similar articles Select item 27072954128.

Minimization of CYP2D6 Polymorphic Differences and Improved Bioavailability via Transdermal Administration: Latrepirdine Example.

Chew ML, Mordenti J, Yeoh T, Ranade G, Qiu R, Fang J, Liang Y, Corrigan B.Pharm Res. 2016 Aug;33(8):1873-80. doi: 10.1007/s11095-016-1922-4. Epub 2016 Apr 12.PMID: 27072954 Similar articlesSelect item 30670877129.

CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.

Smith DM, Weitzel KW, Elsey AR, Langaee T, Gong Y, Wake DT, Duong BQ, Hagen M, Harle CA, Mercado E, Nagoshi Y, Newsom K, Wright A, Rosenberg EI, Starostik P, Clare-Salzler MJ, Schmidt SO, Fillingim RB, Johnson JA, Cavallari LH.Genet Med. 2019 Jan 23. doi: 10.1038/s41436-018-0431-8. [Epub ahead of print]. PMID: 30670877 Similar articlesSelect item 14945979130.

Cure of Korean vivax malaria with pamaquine and primaquine.

GARRISON PL, HANKEY DD, COKER WG, DONOVAN WN, JASTREMSKI B, COATNEY GR, ALVING AS, JONES R Jr.J Am Med Assoc. 1952 Aug 23;149(17):1562-3. No abstract available. PMID: 14945979 Similar articles Select item 26528073131.

Phenotypic differences in nebivolol metabolism and bioavailability in healthy volunteers.

Briciu C, Neag M, Muntean D, Bocsan C, Buzoianu A, Antonescu O, Gheldiu AM, Achim M, Popa A, Vlase L.Clujul Med. 2015;88(2):208-13. doi: 10.15386/cjmed-395. Epub 2015 Apr 15.PMID: 26528073 Free PMC Article Similar articles Select item 21970596132.

Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment.

Lorizio W, Rugo H, Beattie MS, Tchu S, Melese T, Melisko M, Wu AH, Lawrence HJ, Nikoloff M, Ziv E. Genome Med. 2011 Oct 4;3(10):64. doi: 10.1186/gm280.PMID: 21970596 Free PMC Article Similar articles Select item 14419205133.

Use of quinocide in treatment and prophylaxis of vivax malaria.

LYSENKO AY.Bull World Health Organ. 1960;22:641-62.PMID: 14419205 Free PMC Article Similar articles Select item 27223244134.

Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials.

Ding Y, Liu H, Tekwani BL, Nanayakkara NP, Khan IA, Walker LA, Doerksen RJ.

Chem Res Toxicol. 2016 Jul 18;29(7):1132-41. doi: 10.1021/acs.chemrestox.6b00063. Epub 2016 Jul 1.

PMID: 27223244 Similar articles Select item 30650321135.

Tafenoquine - A Radical Improvement?

White NJ.

N Engl J Med. 2019 Jan 17;380(3):285-286. doi: 10.1056/NEJMe1816383. No abstract available.

PMID: 30650321 Similar articlesSelect item 30485867136.

The Associations Between CYP2D6 Metabolizer Status and Pharmacokinetics and Clinical Outcomes of Venlafaxine: A Systematic Review and Meta-Analysis.

Lin XQ, Wang P, Cai WK, Xu GL, Yang M, Zhou MD, Sun M, He F, He GH.

Pharmacopsychiatry. 2018 Nov 28. doi: 10.1055/a-0792-1340. [Epub ahead of print]

PMID: 30485867 Similar articlesSelect item 20343588137.

Pentaquine (SN-13,276) a new antimalarial effective in reducing the relapse rate of vivax malaria.

PULLMAN TN, ALVING AS, et al.

Proc Annu Meet Cent Soc Clin Res U S. 1946 Nov 1-2;19:83. No abstract available.

PMID: 20343588 Similar articlesSelect item 21064280138.

Pamaquin; curative antimalarial activity in vivax malaria.

BERLINER RW, TAGGART JV, et al.

Fed Proc. 1946;5(1 Pt 2):165. No abstract available.

PMID: 21064280 Similar articlesSelect item 23965782139.

Pharmacometric Analyses to Support Early Development Decisions for LY2878735: A Novel Serotonin Norepinephrine Reuptake Inhibitor.

Raddad E, Melhem MR, Sloan-Lancaster JS, Miller JW, Van Wart SA, Rubino CM.

CPT Pharmacometrics Syst Pharmacol. 2013 Aug 21;2:e66. doi: 10.1038/psp.2013.43.

PMID: 23965782 Free PMC Article Similar articles Select item 18872928140.

Study of pentaquine and isopentaquine, therapeutic agents effective in reducing relapse rate in vivax malaria.

ALVING AS.

Abstr Int Congr Trop Med Malar. 1948;56(4th Congr):58. No abstract available.

PMID: 18872928 Similar articles

Combined quinine-plasmochin treatment of vivax malaria; effect of relapse rate.

MOST H, KANE CA, et al.

Am J Med Sci. 1946 Nov;212(5):550-60. No abstract available.

PMID: 20273918 Similar articlesSelect item 29301387142.

Pharmacogenetics of Vascular Risk Factors in Alzheimer's Disease.

Cacabelos R, Meyyazhagan A, Carril JC, Cacabelos P, Teijido Ó.

J Pers Med. 2018 Jan 3;8(1). pii: E3. doi: 10.3390/jpm8010003. Review.

PMID: 29301387 Free PMC Article Similar articles Select item 18905562143.

Combined quinine-plasmochin and quinine-pentaquine treatment of relapsing vivax malaria.

SPICKNALL CG, TERRY LL.

South Med J. 1948 Apr;41(4):338-41. No abstract available.

PMID: 18905562 Similar articles Select item 14790523144.

Radical cure of relapsing vivax malaria with pentaquine-quinine; a controlled study.

STRAUS B, GENNIS J.

Ann Intern Med. 1950 Dec;33(6):1413-22. No abstract available.

PMID: 14790523 Similar articles Select item 18121216145.

Studies in human malaria; the therapeutic action of pamaquine against St. Elizabeth strain vivax malaria.

RUHE DS, COOPER WC, et al.

Am J Hyg. 1949 May;49(3):367-73. No abstract available.

PMID: 18121216 Similar articlesSelect item 18860176146.

Pentaquine (SN-13,276) a therapeutic agent effective in reducing the relapse rate in vivax malaria.

ALVING AS, CRAIGE B Jr, et al.

J Clin Invest. 1948 May;27(3 Pt1):25-33. No abstract available.

PMID: 18860176 Similar articlesSelect item 18860470147.

Evaluation of pentaquine as a cure of relapsing vivax malaria; a controlled study of 95 cases.

STRAUS B, GENNIS J.

Bull N Y Acad Med. 1948 Jun;24(6):395. No abstract available.

PMID: 18860470 Free PMC Article Similar articlesSelect item 14795202148.

Studies in human malaria. XXVII. Observations o­n the use of pentaquine in the prevention and treatment of Chesson strain vivax malaria.

COATNEY GR, COOPER WC, EYLES DE, CULWELL WB, WHITE WC, LINTS HA.

J Natl Malar Soc. 1950 Sep;9(3):222-33. No abstract available.

PMID: 14795202 Similar articlesSelect item 18123173149.

Cure of chronic vivax malaria with pentaquine.

COGGESHALL LT, RICE FA.

J Am Med Assoc. 1949 Feb 12;139(7):437-9. No abstract available.

PMID: 18123173 Similar articlesSelect item 18152607150.

Cure of chronic vivax malaria with pentaquine and status of immunity thereafter.

COGGESHALL LT.

Proc Inst Med Chic. 1949 Jun 15;17(15):357. No abstract available.

PMID: 18152607 Similar articlesSelect item 30137454151.

Tafenoquine receives regulatory approval in USA for prophylaxis of malaria and radical cure of Plasmodium vivax.

Tan KR, Hwang J.

J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay071. No abstract available.

PMID: 30137454 Similar articlesSelect item 24266826152.

On naturalistic pharmacogenetic studies: reply from the authors.

Seip RL, Goethe JW, Schwartz HI, Ruaño G.

Biomark Med. 2013 Dec;7(6):917-8. doi: 10.2217/bmm.13.110. No abstract available.

PMID: 24266826 Free Article Similar articles Select item 29389962153.

Correction: Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.

Silvino ACR, Costa GL, Araújo FCF, Ascher DB, Pires DEV, Fontes CJF, Carvalho LH, Brito CFA, Sousa TN.

PLoS o­ne. 2018 Feb 1;13(2):e0192534. doi: 10.1371/journal.pone.0192534. eCollection 2018.

PMID: 29389962 Free PMC Article Similar articles Select item 28729716154.

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.

Dodgen TM, De J Labuschagne C, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS.

Pharmacogenomics J. 2017 Jul;17(4):393. doi: 10.1038/tpj.2017.20.

PMID: 28729716 Similar articles

Tafenoquine for travelers' malaria: evidence, rationale and recommendations.

Baird JK.

J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay110.

PMID: 30380095 Free PMC Article Similar articles Select item 302294422.

Tafenoquine: First Global Approval.

Frampton JE.

Drugs. 2018 Sep;78(14):1517-1523. doi: 10.1007/s40265-018-0979-2.

PMID: 30229442 Similar articles Select item 288839773.

Management of Plasmodium vivax risk and illness in travelers.

Baird JK.

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Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.

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Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study.

Llanos-Cuentas A, Lacerda MV, Rueangweerayut R, Krudsood S, Gupta SK, Kochar SK, Arthur P, Chuenchom N, Möhrle JJ, Duparc S, Ugwuegbulam C, Kleim JP, Carter N, Green JA, Kellam L.

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Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse.

Walsh DS, Wilairatana P, Tang DB, Heppner DG Jr, Brewer TG, Krudsood S, Silachamroon U, Phumratanaprapin W, Siriyanonda D, Looareesuwan S.

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Fukuda MM, Krudsood S, Mohamed K, Green JA, Warrasak S, Noedl H, Euswas A, Ittiverakul M, Buathong N, Sriwichai S, Miller RS, Ohrt C.

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Suppressive chemoprophylaxis invites avoidable risk of serious illness caused by Plasmodium vivax malaria.

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Malaria surveillance--United States, 1998.

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MMWR CDC Surveill Summ. 2001 Dec 7;50(5):1-20.

PMID: 11770906 Free Article Similar articles Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria.

Baird K.Pathog Glob Health. 2015 May;109(3):93-106. doi: 10.1179/2047773215Y.0000000016. Review.PMID: 25943156 Free PMC Article Similar articlesSelect item 2501612082.

[Two imported and relapsed of Plasmodium vivax malaria cases and primaquine prophylaxis].

Hatipoğlu M, Ulçay A, Turhan V, Karagöz E, Erdem H, Acar A, o­ncül O, Görenek L.Turkiye Parazitol Derg. 2014 Jun;38(2):120-3. doi: 10.5152/tpd.2014.3159. Turkish. PMID: 25016120 Free Article Similar articles Select item 981535183.

Arguments against Chemoprophylaxis in Areas at Low Risk for Chloroquine-Resistant Plasmodium falciparum.

Armengaud M.J Travel Med. 1995 Mar 1;2(1):4-5.PMID: 9815351 Free Article Similar articles Select item 2319949084.

Chemotherapeutic strategies for reducing transmission of Plasmodium vivax malaria.

Douglas NM, John GK, von Seidlein L, Anstey NM, Price RN.Adv Parasitol. 2012;80:271-300. doi: 10.1016/B978-0-12-397900-1.00005-0. Review.PMID: 23199490 Similar articles Select item 1710743185.

Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.

Jiménez BC, Navarro M, Huerga H, López-Román E, Mendoza A, López-Vélez R.J Travel Med. 2006 Nov-Dec;13(6):373-5.PMID: 17107431 Free Article Similar articles Select item 1429600486.

Latent infections with Plasmodium ovale malaria.

MILLER MJ, MARCUS DM, CAMERON DG.Can Med Assoc J. 1965 Jun 12;92:1241-7.PMID: 14296004 Free PMC Article Similar articles Select item 1259463387.

A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum.

Hale BR, Owusu-Agyei S, Fryauff DJ, Koram KA, Adjuik M, Oduro AR, Prescott WR, Baird JK, Nkrumah F, Ritchie TL, Franke ED, Binka FN, Horton J, Hoffman SL.Clin Infect Dis. 2003 Mar 1;36(5):541-9. Epub 2003 Feb 14.PMID: 12594633 Similar articlesSelect item 1683771988.

Imported non-Plasmodium falciparum malaria: a five-year prospective study in a European referral center.

Bottieau E, Clerinx J, Van Den Enden E, Van Esbroeck M, Colebunders R, Van Gompel A, Van Den Ende J.Am J Trop Med Hyg. 2006 Jul;75(1):133-8.PMID: 16837719 Similar articlesSelect item 1681482389.

Gender differences in gastrointestinal disturbances and plasma concentrations of tafenoquine in healthy volunteers after tafenoquine administration for post-exposure vivax malaria prophylaxis.

Edstein MD, Nasveld PE, Kocisko DA, Kitchener SJ, Gatton ML, Rieckmann KH.Trans R Soc Trop Med Hyg. 2007 Mar;101(3):226-30. Epub 2006 Jun 30.PMID: 16814823 Similar articlesSelect item 2845018590.

Prophylactic efficacy of primaquine for preventing Plasmodium falciparum and Plasmodium vivax parasitaemia in travelers: A meta-analysis and systematic review.

Kolifarhood G, Raeisi A, Ranjbar M, Haghdoust AA, Schapira A, Hashemi S, Masoumi-Asl H, Mozafar Saadati H, Azimi S, Khosravi N, Kondrashin A.Travel Med Infect Dis. 2017 May - Jun;17:5-18. doi: 10.1016/j.tmaid.2017.04.005. Epub 2017 Apr 24. Review.PMID: 28450185 Similar articlesSelect item 1242090591.

Malaria surveillance--United States, 1999.

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Exposure-Response Analyses for Tafenoquine after Administration to Patients with Plasmodium vivax Malaria.

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Primaquine treatment for Plasmodium vivax-an essential tool for malaria control and elimination in Papua New Guinea.

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Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.

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Ngày 11/03/2019
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