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 Chuyên đề Nghiên cứu lâm sàng & điều trị
Phần 2: Sốt rét ác tính: nhiều vấn đề liên quan đến cơ chế vẫn chưa sáng tỏ

Nhân loại có 3 kẻ thù quan trọng đó là sốt, đói nghèo và chiến tranh. Trong đó, sốt vẫn được coi là nguy hiểm nhất (“Humanityhasbutthreegreatenemies, Fever,famineandwar:ofthesebyfarthe greatest,byfarthemostterribleisfever -William Osler, 1896). Sốt rét vẫn là vấn đề y tế công cộng nghiêm trọng với tỷ lệ mắc và tử vong tiếp tục giữ vị trí cao trong danh sách các bệnh truyền nhiễm.

Sốt rét ác tính (SRAT) là vấn đề cấp cứu y khoa bởi diễn tiến bệnh nhanh với các biến chứng nghiêm trọng, đe dọa tử vong cao cho nhiều bệnh nhân.

CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses?

Gonçalves RM, Salmazi KC, Santos BA, Bastos MS, Rocha SC, Boscardin SB, Silber AM, Kallás EG, Ferreira MU, Scopel KK.

Infect Immun. 2010 Nov;78(11):4763-72. doi: 10.1128/IAI.00578-10. Epub 2010 Aug 16.

PMID: 20713627 Free PMC Article Similar articles Select item 1677972758.


Hình 1

The distribution and intensity of parasite sequestration in comatose Malawian children.

Seydel KB, Milner DA Jr, Kamiza SB, Molyneux ME, Taylor TE.

J Infect Dis. 2006 Jul 15;194(2):208-5. Epub 2006 Jun 13.

PMID: 16779727 Free PMC ArticleSimilar articles Select item 1279184959.

Devices for rapid diagnosis of Malaria: evaluation of prototype assays that detect Plasmodium falciparum histidine-rich protein 2 and a Plasmodium vivax-specific antigen.

Forney JR, Wongsrichanalai C, Magill AJ, Craig LG, Sirichaisinthop J, Bautista CT, Miller RS, Ockenhouse CF, Kester KE, Aronson NE, Andersen EM, Quino-Ascurra HA, Vidal C, Moran KA, Murray CK, DeWitt CC, Heppner DG, Kain KC, Ballou WR, Gasser RA Jr.

J Clin Microbiol. 2003 Jun;41(6):2358-66.

PMID: 12791849 Free PMC Article Similar articles Select item 139881660.

Genetic red cell defects and malaria.

Sutar NK, Renapurkar DM, Camoens H.

Indian J Med Sci. 1992 Jul;46(7):220-7. No abstract available.

PMID: 1398816Similar articles

A morphometric and histological study of placental malaria shows significant changes to villous architecture in both Plasmodium falciparum and Plasmodium vivax infection.

Chaikitgosiyakul S, Rijken MJ, Muehlenbachs A, Lee SJ, Chaisri U, Viriyavejakul P, Turner GD, Pongponratn E, Nosten F, McGready R.

Malar J. 2014 Jan 4;13:4. doi: 10.1186/1475-2875-13-4.

PMID: 24386908 Free PMC Article Similar articles Select item 2252412862.

Clinical and epidemiological profiles of severe malaria in children from Delhi, India.

Kaushik JS, Gomber S, Dewan P.

J Health Popul Nutr. 2012 Mar;30(1):113-6.

PMID: 22524128 Free PMC Article Similar articles Select item 2302261763.

On the pathogenesis of Plasmodium vivax malaria: perspectives from the Brazilian field.

Costa FT, Lopes SC, Albrecht L, Ataíde R, Siqueira AM, Souza RM, Russell B, Renia L, Marinho CR, Lacerda MV.

Int J Parasitol. 2012 Nov;42(12):1099-105. doi: 10.1016/j.ijpara.2012.08.007. Epub 2012 Sep 26. Review.

PMID: 23022617 Similar articles Select item 1720414964.

Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status.

Duarte J, Deshpande P, Guiyedi V, Mécheri S, Fesel C, Cazenave PA, Mishra GC, Kombila M, Pied S.

Malar J. 2007 Jan 4;6:1.

PMID: 17204149 Free PMC Article Similar articles Select item 2624224365.

Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test.

Tadesse FG, Pett H, Baidjoe A, Lanke K, Grignard L, Sutherland C, Hall T, Drakeley C, Bousema T, Mamo H.

Malar J. 2015 Aug 5;14:303. doi: 10.1186/s12936-015-0821-1.

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Hình 2

Submicroscopic and asymptomatic Plasmodium falciparum and Plasmodium vivax infections are common in western Thailand - molecular and serological evidence.

Baum E, Sattabongkot J, Sirichaisinthop J, Kiattibutr K, Davies DH, Jain A, Lo E, Lee MC, Randall AZ, Molina DM, Liang X, Cui L, Felgner PL, Yan G.

Malar J. 2015 Feb 25;14:95. doi: 10.1186/s12936-015-0611-9.

PMID: 25849211Free PMC Article Similar articles Select item 2323207767.

Local population structure of Plasmodium: impact o­n malaria control and elimination.

Chenet SM, Schneider KA, Villegas L, Escalante AA.

Malar J. 2012 Dec 11;11:412. doi: 10.1186/1475-2875-11-412.

PMID: 23232077 Free PMC Article Similar articles Select item 2573648468.

Ecology of malaria infections in western lowland gorillas inhabiting Dzanga Sangha Protected Areas, Central African Republic.

Mapua MI, Qablan MA, Pomajbíková K, Petrželková KJ, Hůzová Z, Rádrová J, Votýpka J, Todd A, Jirků M, Leendertz FH, Lukeš J, Neel C, Modrý D.

Parasitology. 2015 Jun;142(7):890-900. doi: 10.1017/S0031182015000086. Epub 2015 Mar 4.

PMID: 25736484 Similar articles Select item 2711831169.

History of malaria treatment as a predictor of subsequent subclinical parasitaemia: a cross-sectional survey and malaria case records from three villages in Pailin, western Cambodia.

Peto TJ, Kloprogge SE, Tripura R, Nguon C, Sanann N, Yok S, Heng C, Promnarate C, Chalk J, Song N, Lee SJ, Lubell Y, Dhorda M, Imwong M, White NJ, von Seidlein L, Dondorp A.

Malar J. 2016 Apr 26;15:240. doi: 10.1186/s12936-016-1284-8.

PMID: 27118311 Free PMC Article Similar articles Select item 2325967270.

Plasmodium vivax infection in Anajás, State of Pará: no differential resistance profile among Duffy-negative and Duffy-positive individuals.

Carvalho TA, Queiroz MG, Cardoso GL, Diniz IG, Silva AN, Pinto AY, Guerreiro JF.

Malar J. 2012 Dec 22;11:430. doi: 10.1186/1475-2875-11-430.

PMID: 23259672 Free PMC ArticleSimilar articles Select item 2482708871.

Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax - malaria in India and Saudi Arabia.

Khan W, Zakai HA, Umm-E-Asma.

Acta Parasitol. 2014 Jun;59(2):206-12. doi: 10.2478/s11686-014-0227-1. Epub 2014 May 15.

PMID: 24827088 Similar articles Select item 2375880772.


Hình 3

A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria.

Milner DA Jr, Valim C, Carr RA, Chandak PB, Fosiko NG, Whitten R, Playforth KB, Seydel KB, Kamiza S, Molyneux ME, Taylor TE.

Malar J. 2013 Jun 7;12:191. doi: 10.1186/1475-2875-12-191.

PMID: 23758807 Free PMC Article Similar articles Select item 1216429173.

Field evaluation of the ICT Malaria Pf/Pv immunochromatographic test for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand.

Coleman RE, Maneechai N, Rachapaew N, Kumpitak C, Soyseng V, Miller RS, Thimasarn K, Sattabongkot J.

Am J Trop Med Hyg. 2002 Apr;66(4):379-83.

PMID: 12164291 Similar articles Select item 2767036574.

Severe malaria: what's new o­n the pathogenesis front?

Wassmer SC, Grau GE.

Int J Parasitol. 2017 Feb;47(2-3):145-152. doi: 10.1016/j.ijpara.2016.08.002. Epub 2016 Sep 23. Review.

PMID: 27670365 Free PMC Article Similar articles Select item 1716914275.

Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand.

Coleman RE, Sattabongkot J, Promstaporm S, Maneechai N, Tippayachai B, Kengluecha A, Rachapaew N, Zollner G, Miller RS, Vaughan JA, Thimasarn K, Khuntirat B.

Malar J. 2006 Dec 14;5:121.

PMID: 17169142 Free PMC Article Similar articles Select item 1808601676.


Hình 4

Apoptosis: a potential triggering mechanism of neurological manifestation in Plasmodium falciparum malaria.

Touré FS, Ouwe-Missi-Oukem-Boyer O, Bisvigou U, Moussa O, Rogier C, Pino P, Mazier D, Bisser S.

Parasite Immunol. 2008 Jan;30(1):47-51.

PMID: 18086016 Free Article Similar articles Select item 1864766177.

Dynamic changes in white blood cell counts in uncomplicated Plasmodium falciparum and P. vivax malaria.

Tangpukdee N, Yew HS, Krudsood S, Punyapradit N, Somwong W, Looareesuwan S, Kano S, Wilairatana P.

Parasitol Int. 2008 Dec;57(4):490-4. doi: 10.1016/j.parint.2008.06.005. Epub 2008 Jul 2.

PMID: 18647661 Similar articles Select item 934795178.

Receptor-specific adhesion and clinical disease in Plasmodium falciparum.

Newbold C, Warn P, Black G, Berendt A, Craig A, Snow B, Msobo M, Peshu N, Marsh K.

Am J Trop Med Hyg. 1997 Oct;57(4):389-98.

PMID: 9347951 Similar articles Select item 800921779.

Malaria pathogenesis.

Miller LH, Good MF, Milon G.

Science. 1994 Jun 24;264(5167):1878-83. Review.

PMID: 8009217 Similar articles Select item 2635631180.

Hotspots of Malaria Transmission in the Peruvian Amazon: Rapid Assessment through a Parasitological and Serological Survey.

Rosas-Aguirre A, Speybroeck N, Llanos-Cuentas A, Rosanas-Urgell A, Carrasco-Escobar G, Rodriguez H, Gamboa D, Contreras-Mancilla J, Alava F, Soares IS, Remarque E, D Alessandro U, Erhart A.

PLoS o­ne. 2015 Sep 10;10(9):e0137458. doi: 10.1371/journal.pone.0137458. eCollection 2015.

PMID: 26356311 Free PMC Article Similar articles


Hình 5

Detection of Plasmodium falciparum and Plasmodium vivax subclinical infection in non-endemic region: implications for blood transfusion and malaria epidemiology.

Maselli LM, Levy D, Laporta GZ, Monteiro AM, Fukuya LA, Ferreira-da-Cruz MF, Daniel-Ribeiro CT, Dorlhiac-Llacer PE, Sallum MA, Bydlowski SP.

Malar J. 2014 Jun 6;13:224. doi: 10.1186/1475-2875-13-224.

PMID: 24906577 Free PMC Article Similar articles

Select item 2599661982.

High Rates of Asymptomatic, Sub-microscopic Plasmodium vivax Infection and Disappearing Plasmodium falciparum Malaria in an Area of Low Transmission in Solomon Islands.

Waltmann A, Darcy AW, Harris I, Koepfli C, Lodo J, Vahi V, Piziki D, Shanks GD, Barry AE, Whittaker M, Kazura JW, Mueller I.

PLoS Negl Trop Dis. 2015 May 21;9(5):e0003758. doi: 10.1371/journal.pntd.0003758. eCollection 2015 May.

PMID: 25996619 Free PMC Article Similar articles Select item 2473925083.

Comparison of an assumed versus measured leucocyte count in parasite density calculations in Papua New Guinean children with uncomplicated malaria.

Laman M, Moore BR, Benjamin J, Padapu N, Tarongka N, Siba P, Betuela I, Mueller I, Robinson LJ, Davis TM.

Malar J. 2014 Apr 16;13:145. doi: 10.1186/1475-2875-13-145.

PMID: 24739250 Free PMC Article Similar articles Select item 2617481984.


Hình 6

Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand.

Kuesap J, Chaijaroenkul W, Rungsihirunrat K, Pongjantharasatien K, Na-Bangchang K.

Korean J Parasitol. 2015 Jun;53(3):265-70. doi: 10.3347/kjp.2015.53.3.265. Epub 2015 Jun 30.

PMID: 26174819 Free PMC Article Similar articles Select item 859467985.

Rosette formation by Plasmodium vivax.

Udomsanpetch R, Thanikkul K, Pukrittayakamee S, White NJ.

Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):635-7.

PMID: 8594679 Similar articles Select item 1650402786.

Are insecticide-treated bednets more protective against Plasmodium falciparum than Plasmodium vivax-infected mosquitoes?

Bockarie MJ, Dagoro H.

Malar J. 2006 Feb 21;5:15.

PMID: 16504027 Free PMC Article Similar articles Select item 2503881587.

Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?

Mohanty S, Taylor TE, Kampondeni S, Potchen MJ, Panda P, Majhi M, Mishra SK, Wassmer SC.

Malar J. 2014 Jul 18;13:276. doi: 10.1186/1475-2875-13-276. Review.

PMID: 25038815 Free PMC Article Similar articles Select item 2401943388.

Prevalence and implications of cerebrospinal fluid leukocytosis in Papua New Guinean children hospitalized with severe malaria.

Laman M, Manning L, Siba PM, Davis TM.

Am J Trop Med Hyg. 2013 Nov;89(5):866-8. doi: 10.4269/ajtmh.13-0281. Epub 2013 Sep 9.

PMID: 24019433 Free PMC Article Similar articles Select item 2588907489.


Hình 7

Clinical profile of Plasmodium falciparum and Plasmodium vivax infections in low and unstable malaria transmission settings of Colombia.

Arévalo-Herrera M, Lopez-Perez M, Medina L, Moreno A, Gutierrez JB, Herrera S.

Malar J. 2015 Apr 11;14:154. doi: 10.1186/s12936-015-0678-3.

PMID: 25889074 Free PMC Article Similar articles Select item 2308738990.

A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy.

Barber BE, William T, Grigg MJ, Menon J, Auburn S, Marfurt J, Anstey NM, Yeo TW.

Clin Infect Dis. 2013 Feb;56(3):383-97. doi: 10.1093/cid/cis902. Epub 2012 Oct 19. Erratum in: Clin Infect Dis. 2014 Feb;58(4):608.

PMID: 23087389 Similar articles Select item 2449985191.

Cardiovascular involvement in severe vivax and falciparum malaria.

Nayak KC, Meena SL, Gupta BK, Kumar S, Pareek V.

J Vector Borne Dis. 2013 Dec;50(4):285-91.

PMID: 24499851 Free Article Similar articles Select item 1803909992.

Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease.

Haldar K, Murphy SC, Milner DA, Taylor TE.

Annu Rev Pathol. 2007;2:217-49. Review.

PMID: 18039099 Similar articles Select item 2685129193.


Hình 8

Emerging roles for hemostatic dysfunction in malaria pathogenesis.

O'Sullivan JM, Preston RJ, O'Regan N, O'Donnell JS.

Blood. 2016 May 12;127(19):2281-8. doi: 10.1182/blood-2015-11-636464. Epub 2016 Feb 5. Review.

PMID: 26851291 Free Article Similar articles Select item 2836660394.

Malaria Eradication and the Hidden Parasite Reservoir.

Markus MB.

Trends Parasitol. 2017 Jul;33(7):492-495. doi: 10.1016/j.pt.2017.03.002. Epub 2017 Mar 30.

PMID: 28366603 Similar articles Select item 2512095895.

Pathogenesis of cerebral malaria--inflammation and cytoadherence.

Storm J, Craig AG.

Front Cell Infect Microbiol. 2014 Jul 29;4:100. doi: 10.3389/fcimb.2014.00100. eCollection 2014. Review.

PMID: 25120958 Free PMC Article Similar articles Select item 2657950096.

Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.

Sahu PK, Satpathi S, Behera PK, Mishra SK, Mohanty S, Wassmer SC.

Front Cell Infect Microbiol. 2015 Oct 27;5:75. doi: 10.3389/fcimb.2015.00075. eCollection 2015. Review.

PMID: 26579500 Free PMC Article Similar articles Select item 2704770197.

Severe Malaria Associated with Plasmodium falciparum and P. vivax among Children in Pawe Hospital, Northwest Ethiopia.

Geleta G, Ketema T.

Malar Res Treat. 2016;2016:1240962. doi: 10.1155/2016/1240962. Epub 2016 Mar 7.

PMID: 27047701 Free PMC ArticleSimilar articles Select item 2912074198.

Getting Your Head around Cerebral Malaria.

Dvorin JD.

Cell Host Microbe. 2017 Nov 8;22(5):586-588. doi: 10.1016/j.chom.2017.10.017.

PMID: 29120741 Similar articles Select item 1934702499.


Hình 9

Diagnosis and management of the neurological complications of falciparum malaria.

Mishra SK, Newton CR.

Nat Rev Neurol. 2009 Apr;5(4):189-98. doi: 10.1038/nrneurol.2009.23. Review.

PMID: 19347024 Free PMC Article Similar articles Select item 28579526100.

Overview of human genetic susceptibility to malaria: From parasitemia control to severe disease.

Marquet S.

Infect Genet Evol. 2017 Jun 1. pii: S1567-1348(17)30188-0. doi: 10.1016/j.meegid.2017.06.001. [Epub ahead of print]

PMID: 28579526 Similar articles


Hình 10

Do we know enough to find an adjunctive therapy for cerebral malaria in African children?

Riggle BA, Miller LH, Pierce SK.

F1000Res. 2017 Nov 22;6:2039. doi: 10.12688/f1000research.12401.1. eCollection 2017. Review.

PMID: 29250318 Free PMC Article Similar articles Select item 26941390102.

The heads and the tails of malaria and VWF.

Montgomery RR.

Blood. 2016 Mar 3;127(9):1081-2. doi: 10.1182/blood-2015-11-679878.

PMID: 26941390 Free Article Similar articles Select item 29249333103.

Beyond Hemoglobin: Screening for Malaria Host Factors.

Egan ES.

Trends Genet. 2017 Dec 14. pii: S0168-9525(17)30206-8. doi: 10.1016/j.tig.2017.11.004. [Epub ahead of print] Review.

PMID: 29249333 Similar articles Select item 29206655104.

Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.

Plewes K, Turner GDH, Dondorp AM.

Curr Opin Infect Dis. 2018 Feb;31(1):69-77. doi: 10.1097/QCO.0000000000000419.

PMID: 29206655 Free PMC Article Similar articles Select item 20665090105.

Malaria: origin of the term "hypnozoite".

Markus MB.

J Hist Biol. 2011 Winter;44(4):781-6. doi: 10.1007/s10739-010-9239-3.

PMID: 20665090 Similar articles Select item 339705106.

Diet and cerebral malaria: the effect of famine and refeeding.

Murray MJ, Murray AB, Murray NJ, Murray MB.

Am J Clin Nutr. 1978 Jan;31(1):57-61.

PMID: 339705 Similar articles Select item 29313484107.

New Syndromes Identified by Neuroimaging during Cerebral Malaria.

Hoffmann A, Wassmer SC.

Am J Trop Med Hyg. 2018 Feb;98(2):349-350. doi: 10.4269/ajtmh.17-0926. Epub 2018 Jan 4. No abstract available.

PMID: 29313484 Free PMC Article Similar articles

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

Samuel C. Wassmer, Terrie E. Taylor, Pradipsinh K. Rathod, Saroj K. Mishra, Sanjib Mohanty, Myriam Arevalo-Herrera, Manoj T. Duraisingh, Joseph D. Smith

Am J Trop Med Hyg. 2015 Sep 2; 93(3 Suppl): 42–56. doi: 10.4269/ajtmh.14-0841

PMCID: PMC4574273 Article PubReader PDF–1.0MCitation


Hình 11

The draft genome of Kipferlia bialata reveals reductive genome evolution in fornicate parasites

Goro Tanifuji, Shun Takabayashi, Keitaro Kume, Mizue Takagi, Takuro Nakayama, Ryoma Kamikawa, Yuji Inagaki, Tetsuo Hashimoto

PLoS o­ne. 2018; 13(3): e0194487. Published o­nline 2018 Mar 28. doi: 10.1371/journal.pone.0194487

PMCID: PMC5874029 Article PubReader PDF–5.1MCitation

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65

Diletta Scaccabarozzi, Katrien Deroost, Yolanda Corbett, Natacha Lays, Paola Corsetto, Fausta Omodeo Salè, Philippe E. Van den Steen, Donatella Taramelli

Malar J. 2018; 17: 18. Published o­nline 2018 Jan 9. doi: 10.1186/s12936-017-2159-3

PMCID: PMC5761140 Article PubReader PDF–1.3MCitation

Do we know enough to find an adjunctive therapy for cerebral malaria in African children?

Brittany A. Riggle, Louis H. Miller, Susan K. Pierce

Version 1. F1000Res. 2017; 6: 2039. Published o­nline 2017 Nov 22. doi: 10.12688/f1000research.12401.1

PMCID: PMC5701444 Article PubReader PDF–730KCitation


Hình 12

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

Estela Shabani, Benjamin Hanisch, Robert O. Opoka, Thomas Lavstsen, Chandy C. John

BMC Med. 2017; 15: 183. Published o­nline 2017 Oct 13. doi: 10.1186/s12916-017-0945-y

PMCID: PMC5639490 Article PubReader PDF–1.0MCitation

Complicated malaria in children and adults from three settings of the Colombian Pacific Coast: A prospective study

Myriam Arévalo-Herrera, Lina Rengifo, Mary Lopez-Perez, Maria I. Arce-Plata, Jhon García, Sócrates Herrera

PLoS o­ne. 2017; 12(9): e0185435. Published o­nline 2017 Sep 25. doi: 10.1371/journal.pone.0185435

PMCID: PMC5612730 Article PubReader PDF–3.1MCitation

Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms

Adam Kim, Jean Popovici, Amélie Vantaux, Reingsey Samreth, Sophalai Bin, Saorin Kim, Camille Roesch, Li Liang, Huw Davies, Philip Felgner, Sócrates Herrera, Myriam Arévalo-Herrera, Didier Ménard, David Serre

Sci Rep. 2017; 7: 7761. Published o­nline 2017 Aug 10. doi: 10.1038/s41598-017-07275-9

PMCID: PMC5552866 Article PubReader PDF–1.4MCitation


Hình 13

Single-molecule analysis reveals that DNA replication dynamics vary across the course of schizogony in the malaria parasite Plasmodium falciparum

Slavica Stanojcic, Nada Kuk, Imran Ullah, Yvon Sterkers, Catherine J. Merrick

Sci Rep. 2017; 7: 4003. Published o­nline 2017 Jun 21. doi: 10.1038/s41598-017-04407-z

PMCID: PMC5479783 Article PubReader PDF–2.0MCitation

Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque Resulted in Similar Histopathological Changes as Those Seen in Human Malaria

Chester J. Joyner, The MaHPIC Consortium, Jennifer S. Wood, Alberto Moreno, Anapatricia Garcia, Mary R. Galinski

Am J Trop Med Hyg. 2017 Aug 2; 97(2): 548–555. Published o­nline 2017 Jun 5. doi: 10.4269/ajtmh.16-0742

PMCID: PMC5544077Currently embargoed: Free in PMC o­n Aug 2, 2018; PubMed

Epidemiology of Plasmodium vivax Malaria in India

Anupkumar R. Anvikar, Naman Shah, Akshay C. Dhariwal, Gagan Singh Sonal, Madan Mohan Pradhan, Susanta K. Ghosh, Neena Valecha

Am J Trop Med Hyg. 2016 Dec 28; 95(6 Suppl): 108–120. doi: 10.4269/ajtmh.16-0163

PMCID: PMC5201217 Article PubReader PDF–7.5MCitation

EPCR and malaria severity: the center of a perfect storm

Maria Bernabeu, Joseph D. Smith

Trends Parasitol.

Published in final edited form as: Trends Parasitol. 2017 Apr; 33(4): 295–308. Published o­nline 2016 Dec 6. doi: 10.1016/j.pt.2016.11.004

PMCID: PMC5376506 Article PubReader PDF–1.2MCitation

Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content

Natalia Tiberti, Sharissa L. Latham, Stephen Bush, Amy Cohen, Robert O. Opoka, Chandy C. John, Annette Juillard, Georges E. Grau, Valéry Combes

Sci Rep. 2016; 6: 37871. Published o­nline 2016 Dec 5. doi: 10.1038/srep37871

PMCID: PMC5137300 Article PubReader PDF–1.6MCitation

Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa

J L Baker, D Shriner, A R Bentley, C N Rotimi

Pharmacogenomics J. 2017 Mar; 17(2): 112–120. Published o­nline 2016 Oct 25. doi: 10.1038/tpj.2016.78

PMCID: PMC5380847 Article PubReader PDF–410KCitation

Natural Mosquito-Pathogen Hybrid IgG4 Antibodies in Vector-Borne Diseases: A Hypothesis

Berlin Londono-Renteria, Jenny C. Cardenas, Andrea Troupin, Tonya M. Colpitts

Front Immunol. 2016; 7: 380. Published o­nline 2016 Sep 29. doi: 10.3389/fimmu.2016.00380

PMCID: PMC5040711 Article PubReader PDF–1.5MCitation

Severe malaria: what’s new o­n the pathogenesis front?

Samuel Crocodile Wassmer, Georges Emile Raymond Grau

Int J Parasitol.

Published in final edited form as: Int J Parasitol. 2017 Feb; 47(2-3): 145–152. Published o­nline 2016 Sep 23. doi: 10.1016/j.ijpara.2016.08.002

PMCID: PMC5285481 Article PubReader PDF–367KCitation

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

Jakob S Jespersen, Christian W Wang, Sixbert I Mkumbaye, Daniel TR Minja, Bent Petersen, Louise Turner, Jens EV Petersen, John PA Lusingu, Thor G Theander, Thomas Lavstsen

EMBO Mol Med. 2016 Aug; 8(8): 839–850. Published o­nline 2016 Jun 27. doi: 10.15252/emmm.201606188

PMCID: PMC4967939 Article PubReader PDF–573KCitation

Tying malaria and microRNAs: from the biology to future diagnostic perspectives

Mercedes Rubio, Quique Bassat, Xavier Estivill, Alfredo Mayor

Malar J. 2016; 15: 167. Published o­nline 2016 Mar 15. doi: 10.1186/s12936-016-1222-9

PMCID: PMC4793504 Article PubReader PDF–1.4MCitation

Cardiovascular changes in patients with non-severe Plasmodium vivax malaria

Aristoteles Comte Alencar-Filho, Joao Marcos Bemfica Barbosa Ferreira, Jorge Luis Salinas, Camila Fabbri, Wuelton Marcelo Monteiro, Andre Machado Siqueira, Katashi Okoshi, Marcus Vinicius Guimaraes Lacerda, Marina Politi Okoshi

Int J Cardiol Heart Vasc. 2016 Jun; 11: 12–16. Published o­nline 2016 Mar 10. doi: 10.1016/j.ijcha.2016.03.004

PMCID: PMC5441355 Article PubReader PDF–255KCitation

Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum

Catherine J. Merrick

Malar J. 2015; 14: 490. Published o­nline 2015 Dec 2. doi: 10.1186/s12936-015-1014-7

PMCID: PMC4668656 Article PubReader PDF–1.5MCitation

Glycophorins, blood groups, and protection from severe malaria

Samuel C. Wassmer, Jane M. Carlton

Trends Parasitol.

Published in final edited form as: Trends Parasitol. 2016 Jan; 32(1): 5–7. Published o­nline 2015 Nov 21. doi: 10.1016/j.pt.2015.11.006

PMCID: PMC4713327 Article PubReader PDF–439KCitation

Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches

Praveen K. Sahu, Sanghamitra Satpathi, Prativa K. Behera, Saroj K. Mishra, Sanjib Mohanty, Samuel Crocodile Wassmer

Front Cell Infect Microbiol. 2015; 5: 75. Published o­nline 2015 Oct 27. doi: 10.3389/fcimb.2015.00075

PMCID: PMC4621481 Article PubReader PDF–815KCitation

Ngày 26/06/2018
TS.BS. Huỳnh Hồng Quang  

THÔNG BÁO

   Dịch vụ khám chữa bệnh chuyên ngành của Viện Sốt rét-Ký sinh trùng-Côn trùng Quy Nhơn thuộc Bộ Y tế về các bệnh ký sinh trùng và các bệnh do véc tơ truyền, đặc biệt là các bệnh ký sinh trùng mới nổi như sán lá gan lớn, sán lá gan nhỏ, giun lươn, giun đũa chó và các bệnh thông thường khác; khám bảo hiểm y tế và xét nghiệm chẩn đoán bệnh bằng các phương tiện kỹ thuật cao như sinh hóa, huyết học, miễn dịch (ELISA), sinh học phân tử và chẩn đoán hình ảnh bằng nội soi tiêu hóa, siêu âm màu…

   Trung tâm Dịch vụ khoa học kỹ thuật của Viện Sốt rét-Ký sinh trùng-Côn trùng Quy Nhơn thuộc Bộ Y tế chuyên sản xuất mua bán hóa chất, vật tư, chế phẩm diệt côn trùng; dịch vụ diệt côn trùng gây bệnh, côn trùng gia dụng như muỗi, ruồi, gián, kiến…; dịch vụ phòng diệt mối mọt và xét nghiệm phát hiện tôm bằng các kỹ thuật hiện đại.


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