The end of a dogma: the safety of doxycycline use in young children for malaria treatment; Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (AC...; Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet and Bruno Pradines; Malaria Journal201716:148
Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes:The clinical utility of primaquine (PQ), used as a racemic mixture of two enantiomers, is limited due to metabolism-linked hemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehyd...Pius S. Fasinu, Bharathi Avula, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Yan-Hong Wang, H. M. T. Bandara Herath, James D. McChesney, Gregory A. Reichard, Sean R. Marcsisin, Mahmoud A. Elsohly, Shabana I. Khan, Ikhlas A. Khan and Larry A. Walker. Malaria Journal 2016 15:224
Exceptionally long-range haplotypes in Plasmodium falciparum chromosome 6 maintained in an endemic African population: Previous genome-wide analyses of single nucleotide variation in Plasmodium falciparum identified evidence of an extended haplotype region on chromosome 6 in West Africa, suggesting recent positive selection. Such...Alfred Amambua-Ngwa, Bakary Danso, Archibald Worwui, Sukai Ceesay, Nwakanma Davies, David Jeffries, Umberto D’Alessandro and David Conway Malaria Journal 2016 15:515